急性肺损伤的发病机制及间充质干细胞治疗作用的研究进展

The pathogenesis of acute lung injury and the treatment effect of mesenchymal stem cells

急性肺损伤(acute lung injury,ALI)和急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是以急性、进行性加重的呼吸困难、难治性低氧血症、双侧肺浸润为特点的临床综合征,其发病率和病死率高.干细胞是一类具有较强分化功能的细胞,可以分化成内皮细胞、上皮细胞、脂肪细胞和软骨细胞等各种类型的细胞.骨髓间充质干细胞(mesenchymal stem cell,MSC)在再生疗法与免疫调节方面的治疗潜力和安全性已成为研究的热点.大量研究证明MSC可通过多种途径来治疗肺损伤,但具体调节机制尚不清楚.因此该文就ALl的机制及MSC在ALI中的作用进行综述.

Acute lung injury and acute respiratory distress syndrome are characterized by acute,progressive dyspnea,refractory hypoxemia and bilateral pulmonary innfiltrates.Stem cell is a type of cell with strong differentiation function,which can differentiate into various types of cells,such as endothelial cells,epithelial cells,adipocytes and chondrocytes.The therapeutic potential and safety of mesenchymal stem cells (MSCs) in regenerative therapy and immune regulation have become the research hotspot.A large number of studies have shown that MSC can be used to treat lung injury in many ways,but the specific mechanism is not clear.Therefore,the mechanism of acute lung injury and the therapeutic effects of marrow MSC in acute lung injury will be reviewed in this paper.