益生菌对儿童肥胖症治疗的研究进展

Progress of probiotic's effect on childhood obesity treatment

近年来,儿童肥胖症的发生率逐渐升高,肥胖患儿逐渐增多.大量研究证实儿童期的肥胖不仅会影响儿童的身心健康,同时也会增加其成年罹患各种代谢性疾病的发生率.益生菌是一类活微生物,现临床上将益生菌生物制剂广泛应用于治疗各种胃肠道疾病.目前发现,肥胖患儿肠道内的微生物的多样性降低、耐氧菌数量增加.已有研究显示,某些益生菌制剂可有效改善机体肠道微生态环境,而肠道内某些优势菌群可以针对性地对脂肪细胞起直接作用,改善机体低度炎症状态,对机体进行免疫调节,从而起到降低体重的作用.该文通过对国内外相关研究进行汇总,证实益生菌对肥胖患儿减轻体重确有临床意义,希望通过进一步的研究,找到更多解决儿童肥胖的途径.

In recent years,the incidence rate of childhood obesity has been growing gradually,and the number of obese child has been increased.Studies have shown that obesity in childhood not only impairs children's physical and mental health,but also increase the chance of metabolic disease in his adulthood.Probiotic is a kind of live microbe.Nowadays,probiotic biological preparations are widely used to treat various gastrointestinal diseases.It is currently found that compared with the normal child the degree of microbial diversity in obese child's intestine is lower,and the number of aerotorelant bacteria is increasing.Some probiotic preparations can effectively improve body's intestinal microenvironment,and some predominant flora in the gut can be targeted to adipose cells directly,improving the body of low-grade inflammation state,adjusting immune function,and thus playing a role in reducing weight.By summarizing the relevant researches at home and abroad,this paper proves that probiotics have clinical significance in reducing weight of obese children,hoping to find out more ways to solve childhood obesity through further research.