扩散张量成像在肥胖儿童脑白质完整性研究中的应用

Diffusion tensor imaging in children with obesity

儿童肥胖症是一种由多基因遗传和环境因素等共同作用的复杂病症.能量摄入多于能量消耗导致脂肪积累是肥胖的主要原因,神经内分泌调节参与肥胖的发病过程.神经纤维是神经系统的基本结构和功能单位,研究神经纤维分布与儿童肥胖的关系,可能为肥胖的发病机制做出有益的探索.扩散张量成像是一种被广泛应用于临床的磁共振成像技术,是一种成熟的用于观察人大脑白质纤维走行的技术手段,可以图像化和可视化的直观显示颅内改变,并通过描述白质纤维之间的关系,以观察脑白质完整性的破坏与否,从而反映大脑结构和功能信息,对脑的发育疾病诊断有重要的意义,但在肥胖儿童中的研究较少,现就在儿童肥胖的研究进展予以综述.

Childhood obesity is a complex disease that is caused by potygene inheritance and environmental factors.It is the main cause of obesity that energy intake is more than energy consumption.Neuroendocrine regulation participates in the pathogenesis of obesity.Nerve fibers are the basic structure and functional units of the nervous system.The study of the relationship between the distribution of nerve fibers and obesity in children may be a useful exploration for the pathogenesis of obesity.Diffusion tensor imaging (DTI) is a widely used magnetic resonance imaging (MRI) technique.It is a mature technique for observing human white matter fibers.It is an important technique to display the the tacts of the white matter,The diagnosis of the disease and the changes of the central nervous system can be deterined by describing the relationship between the white matter fibers and observing whether the integrity of the white matter is destroyed or not,so as to reflect the structure and function of the brain.But in obese children,the research is lacking.The application of DTI in childhood obesity research is reviewed in this article.