色氨酸分解代谢与儿童过敏性疾病

Role of tryptophan catabolism in pediatric allergic diseases

随着环境及生活方式改变,儿童过敏性疾病发病率呈增高趋势,但其发病机制未完全阐明.有研究发现吲哚胺2,3-双加氧酶(indoleamine 2,3-dioxygenase,IDO)介导的色氨酸分解代谢在儿童过敏性疾病如哮喘、过敏性鼻炎的发病及在过敏性疾病特异性免疫治疗中起重要作用.IDO介导的色氨酸分解代谢包括诱导Treg产生,抑制Th2细胞反应,介导免疫耐受等.因此,通过刺激免疫细胞及改变饮食结构调控色氨酸分解代谢将是防治过敏性疾病的新靶点.该文对色氨酸分解代谢在儿童过敏性疾病中的作用进行综述.

With the change of environment and life-style,the incidence of allergic diseases in children is increasing,but its pathogenesis is not entirely elucidated.It is shown that tryptophan catabolism mediated by indoleamine 2,3-dioxygenase plays a significant role in the pathophysiology of allergic diseases of children such as asthma and allergic rhinitis.These roles include inducing Treg cell,inhibiting Th2 cell response,mediating immune tolerance and so forth.Therefore,it is a new target for the prevention and treatment of allergic diseases by stimulating the immune cells and changing the diet structure to regulate tryptophan catabolism.This article reviews the role of tryptophan decomposition in children allergic diseases.