儿童多发性硬化治疗研究进展

Advances in the treatment of multiple sclerosis in children

多发性硬化(multiple sclerosis,MS)是一种以中枢神经系统白质损害为主要特征的最重要的自身免疫性疾病之一,MS患者中约有2.2％ ～4.4％为儿童病例,因此儿童MS的发病情况近几年来越来越多的受到人们的关注.约80％的儿科病例和几乎所有的青春期患者的临床发作与成人相似,儿童MS的治疗与成人相似,97％～99％的患儿表现为复发缓解型,明显高于成人患者所占比例.儿童MS治疗虽然与成人相似,但也有其自身特点,该文重点对儿童MS的治疗进展作一综述.

Multiple sclerosis (MS) is one of the most important autoimmune diseases characterized mainly by white matter damage in the central nervous system.A total of 2.2％ to 4.4％ of MS population are children and adolescence,which has attracted increasing attention.About 80％ of the pediatric cases and nearly all adolescent onset patients present with attacks typical to adult MS.Approximately 97％ to 99％ of the affected children suffer relapsing-remitting MS,which is higher than that of the adults.MS in children is associated with more frequent and severe relapses.The treatment of MS in children is similar with that in adults,but with their own characteristics.The review focuses on the progress in the treatment of MS in children.