儿童肠屏障功能障碍发病机制的研究进展

Advances in pathogenesis of intestinal barrier dysfunction in children

肠屏障功能障碍是指由多种因素导致的肠道黏膜层的损伤甚至萎缩、肠内微生物群的紊乱失调以及肠道通透性的增加,致使如细菌和(或)内毒素易位进入体内其他组织器官和(或)血液循环,诱发和(或)加重全身多器官功能障碍和炎症反应.肠屏障的破坏与许多胃肠道疾病有关,但也伴有肠外病变,如过敏性疾病.因此维持正常功能肠屏障对儿童至关重要.目前对于儿童肠屏障功能障碍的研究相对较少,该文对近年来儿童肠道屏障发病机制研究进展作一综述.

Intestinal barrier dysfunction refers to the damage or even atrophy of the intestinal mucosa,disorder of intestinal microbial population and increased intestinal permeability caused by a variety of factors,resulting in the insertion of bacterial and/or endotoxin translocation into other tissues and/or blood circulation,induction and/or aggravation systemic multiple organ dysfunction and inflammatory response.The destruction of the intestinal barrier is associated with many gastrointestinal disorders,bur also accompanied by parenteral pathological conditions,such as allergic diseases.Therefore,maintaining a healthy intestinal barrier is critical to children.At present,there are relatively few studies on the intestinal barrier dysfunction in children.This paper reviews the recent progress in the pathogenesis of intestinal barrier in children.