儿童系统性红斑狼疮并发骨梗死的研究进展

Progress of osteonecrosis in children with systemic lupus erythematosus

系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种多系统损害的慢性自身免疫性疾病,骨梗死是SLE常见的并发症之一,也是SLE致残的主要原因.SLE并发骨梗死可表现为局部关节疼痛或行走困难,也可无任何症状.骨梗死的发生与多种因素相关,除长期使用糖皮质激素外,SLE疾病本身、免疫抑制剂的使用及基因学背景也是SLE并发骨梗死的重要因素.该文就SLE并发骨梗死的临床表现、危险因素及诊治进展加以综述,以期提高临床医生对儿童SLE并发骨梗死的认识.

Systemic lupus erythematosus (SLE)isa chronic multisystem autoimmune disease.Osteonecrosis is a common complication of SLE and the main cause of disability.The clinical manifestations of osteonecrosis could be joint pain,difficulty in walking,or asymptomatic.The development of osteonecrosis is related to various factors.In addition to the long-term use of corticosteroids,the typical features of SLE,the administration of immunosuppressives and gene polymorphisms are also the main factors for the development of osteonecrosis in SLE.In order to improve the understanding of osteonecrosis in children with SLE,this article reviews the clinical manifestations,the risk factors and treatment of osteonecrosis in SLE.