291例发热伴血小板减少综合征患者生存分析

Survival analysis on 291 cases of fever with thrombocytopenia syndrome

目的 探讨发热伴血小板减少综合征(SFTS)患者的死亡危险因子.方法 收集2013年5月至2016年8月期间在烟台市传染病医院收治的291例SFTS患者的临床资料,通过查阅文献并结合临床实践,确定观察因素并建立Cox回归模型进行统计学分析.结果 SFTS及相关并发症死亡75例,死亡患者发病后的生存时间为(9.32±3.33)d,死亡高峰时间发生在第6～12天.神经系统损害、早期心电图异常、发热期延长、年龄(45-59岁,60～74岁,≥75岁)与基础疾病为SFTS患者的死亡风险因素(HR=15.491、9.624、2.579、1.539、2.235、2.428和1.980).结论 临床接诊时,若患者早期即合并多种死亡风险因素,应及时监测患者病情进展.

Objective To explore the risk factor for death in patients of fever with thrombocytopenia syndrome(SFTS).Methods A total of 291 SFTS patients in Yantai Infectious Disease Hospital were collected from May,2013 to August,2016.The inspection factors were determined and Cox regression model was established for statistical analysis by reviewing literature with clinical practice.Results There were 75 death cases due to SFTS and relative complications.The survival time of death patients after incidence was average (9.32±3.33) d,with the peak time of death during 6th to 12th day.Body mandible jitter,early abnormal ECG,fever duration,age (45-59 years old,60-74 years old,and ≥75 years old) and basic diseases were risk factors for death of SFTS patients (HR=15.491,9.624,2.579,1.539,2.235,2.428 and 1.980,respectively).Conclusions If patients in early stage have combinated various risk factors,their condition should be monitored in time.