摘要
Objective The aim of the present study was to assess clinical outcomes of patients with angiosarcoma of the scalp and face and factors associated with prognosis,as well as to investigate the deregulation of the mechanistic/mammalian target of rapamycin (mTOR) signaling pathway in the disease.Methods We retrospectively analyzed the clincial data of 23 patients with localized angiosarcoma of the scalp and face,who were diagnosed between 2010 and 2016 in the Peking Union Medical College Hospital.Surgically resected or biopsy samples were collected,and immunohistochemical analysis was performed to detect expression of the mTOR pathway-related proteins.Results Twenty-three patients were included in the study.The median overall survival (OS) was 26.0 months at a median follow-up of 13 months.One-year and 3-year OS were 73.5％ and 21.8％,respectively.Univariate analysis showed that:1) Age 70 years or older (vs.＜ 70 years) was associated with poor prognosis (8.0 months vs.33.0 months,P =0.001);2) Tumors larger than 5 cm (vs.≤ 5 cm) were associated with decreased OS (13.0 months vs.33.0 months,P =0.02).Overexpression of phosphorylated (p-) protein kinase B (AKT) at Ser473,p-AKT at Thr308,p-mTOR at Ser2448,and p-p70-S6K1 at Thr421/Ser424 were observed in 13.0％,78.3％,47.8％,and 21.7％ of patients,respec-tively.Conclusions Angiosarcoma of the scalp and face is highly aggressive with limited treatment options and poor clinical outcomes.Younger age and more localized disease were associated with improved outcomes.Activation of the AKT/mTOR complex 1 pathway is common in the disease,while abnormal activation of p70S6K1 is not significant.Furthermore,overexpression of mTOR complex 2 is observed in part cases.
Objective The aim of the present study was to assess clinical outcomes of patients with angiosarcoma of the scalp and face and factors associated with prognosis,as well as to investigate the deregulation of the mechanistic/mammalian target of rapamycin (mTOR) signaling pathway in the disease.Methods We retrospectively analyzed the clincial data of 23 patients with localized angiosarcoma of the scalp and face,who were diagnosed between 2010 and 2016 in the Peking Union Medical College Hospital.Surgically resected or biopsy samples were collected,and immunohistochemical analysis was performed to detect expression of the mTOR pathway-related proteins.Results Twenty-three patients were included in the study.The median overall survival (OS) was 26.0 months at a median follow-up of 13 months.One-year and 3-year OS were 73.5％ and 21.8％,respectively.Univariate analysis showed that:1) Age 70 years or older (vs.＜ 70 years) was associated with poor prognosis (8.0 months vs.33.0 months,P =0.001);2) Tumors larger than 5 cm (vs.≤ 5 cm) were associated with decreased OS (13.0 months vs.33.0 months,P =0.02).Overexpression of phosphorylated (p-) protein kinase B (AKT) at Ser473,p-AKT at Thr308,p-mTOR at Ser2448,and p-p70-S6K1 at Thr421/Ser424 were observed in 13.0％,78.3％,47.8％,and 21.7％ of patients,respec-tively.Conclusions Angiosarcoma of the scalp and face is highly aggressive with limited treatment options and poor clinical outcomes.Younger age and more localized disease were associated with improved outcomes.Activation of the AKT/mTOR complex 1 pathway is common in the disease,while abnormal activation of p70S6K1 is not significant.Furthermore,overexpression of mTOR complex 2 is observed in part cases.
