非小细胞肺癌纵隔淋巴结转移术前诊断的研究现状及进展

Current status and progress of preoperative diagnosis of mediastinal lymph node metastasis of non-small cell lung cancer

近年来,肺癌的发病率、病死率居高不下,成为威胁人类健康和生命的主要疾病之一.非小细胞肺癌的术前分期,尤其是纵隔淋巴结分期是决定能否手术并判断患者预后的关键.因此如何实现纵隔淋巴结术前准确的分期是临床上亟需解决的问题.传统的纵隔淋巴结术前分期方法主要包括影像学、微创活检及外科手术等,近年来相关血清肿瘤标志物、血清miRNA及临床预测模型等的发展,为纵隔淋巴结转移术前诊断和评估提供了一些新的参考.本文综述近年来非小细胞肺癌纵隔淋巴结转移术前诊断的各种方法,并对各种方法的利弊进行总结及分析.

In recent years,the incidence of lung cancer,high mortality,become one of the main diseases that threaten human health and life.Preoperative staging of non-small cell lung cancer,especially mediastinal lymph node staging is the key to determine whether surgery and judge tne prognosis of patients.Therefore,how to achieve accurate staging of mediastinal lymph node before surgery is a clinical problem to be solved urgently.The traditional methods of preoperative staging of mediastinal lymph nodes include imaging,minimally invasive biopsy and surgery.In recent years,the development of relevant serum tumor markers,serum miRNAs and clinical prediction models provide some new references for the preoperative diagnosis and assessment of mediastinal lymph node metastasis.This paper reviews the methods of preoperative diagnosis of mediastinal lymph node metastasis of non-small cell lung cancer in recent years,and summarizes and analyzes the advantages and disadvantages of various methods.