腹腔镜胆道探查一期缝合术后胆漏的危险因素分析

Analysis of risk factors of bile leakage in patients after laparoscopic common bile duct exploration and primary suture

目的 探讨腹腔镜胆道探查一期缝合术后胆漏的危险因素,为降低术后胆漏提供依据.方法 回顾性分析2012年10月-2017年3月193例接受腹腔镜胆道探查一期缝合手术治疗胆总管结石患者的临床资料,根据术后是否发生胆漏分为胆漏组(23例)和无胆漏组(170例).对可能与术后胆漏发生有关的黄疸、胆汁性状、泥沙样结石等21个因素进行单因素分析及Logistic回归多因素分析,从而判定影响术后胆漏发生的危险因素.计数资料用频数和百分数表示,组间比较用x2检验.等级资料用频数和百分数表示,组间比较用秩和检验.多因素分析用逐步Logistic回归.结果 全组胆漏发病率11.92％(23/193).单因素分析结果显示,合并胆管炎、黄疸、胆汁性状、泥沙样结石、结石数量、结石嵌顿、乳头开闭蠕动情况与术后胆漏的发生相关(x2或Z值=2.537,2.122,81.834,50.709,13.242,26.958,90.207,P＜0.05).多因素分析结果显示胆汁性状、泥沙样结石、结石嵌顿和乳头开闭蠕动情况是术后胆漏发生的独立危险因素(Wals=14.002,8.899,6.577,5.582,P＜0.05).结论 胆汁性状、泥沙样结石、结石嵌顿和乳头开闭蠕动情况是腹腔镜胆道探查一期缝合术后胆漏发生的主要危险因素.

Objective To explore the risk factors of bile leakage in patients with laparoscopic common bile duct exploration and primary suture for the purpose of providing clues for reducing occurrence of bile leakage.Methods The clinic data of 193 choledocholithiasis patients with laparoscopic common bile duct exploration and primary suture from October 2012 to March 2017 were retrospective analysed.All patients were divided into bile leakage group (23 patients) and non-bile leakage group (170 patients).Risk factors influencing the incidence of bile leakage were determined by analyzing 21 relevant factors with one-way analysis of variance and Logistic multivariate regression analysis.Count data and ordinal data was expressed as frequency or a percentage.Chi-square test was used to compare with groups of count data,rank-sum test was for comparison between groups of ordinal data,and Logistic regression was for multivariate analysis.Results Among all the patients,the incidence of bile leakage was 11.92％ (23/193).The results of univariate analysis revealed that cholangitis,jaundice,bile characteristics,muddy stone,number of stones,incarcerated stone,open and close peristalsis of duodenal papilla were correlated with bile leakage (x2/Z =2.537,2.122,81.834,50.709,13.242,26.958,90.207,P ＜0.05).The result of multivariate analysis revealed that bile characteristics,muddy stone,incarcerated stone,open and close peristalsis of duodenal papilla was correlated with bile leakage (Wals =14.002,8.899,6.577,5.582,P ＜0.05).Conclusion Bile characteristics,muddy stone,incarcerated stone,open and close peristalsis of duodenal papilla were main risk factors of bile leakage in patients with laparoscopic common bile duct exploration and primary suture.