NF-κB的激活和氧化应激与抗氧化剂治疗急性胰腺炎的研究进展

Research progress of NF-κB's activation and oxidative stress and antioxidants in the treatment of acute pancreatitis

急性胰腺炎是胰酶激活后引起胰腺组织自身消化所致的急性炎性介质反应,可诱发全身炎性介质反应,并恶化为多脏器功能衰竭,甚至可能导致患者死亡.近年来,大量的研究数据证实了核因子-κB的激活和氧化应激在急性胰腺炎发生、发展过程具有损伤和促进作用.因此抗氧化剂能否治疗急性胰腺炎,防止并发症成为一个研究方向,多个相关的临床研究和动物实验研究证实单独或联合使用抗氧化剂对急性胰腺炎患者或动物模型是有益的,对于预防感染等并发症有一定疗效.同时,更多类型的抗氧化剂如多种植物提取物在动物模型上的研究取得了相应的进展.本文通过回顾相关实验和临床研究文献,将核因子-κB的激活和氧化应激对急性胰腺炎的损伤作用和抗氧化剂治疗急性胰腺炎的相关研究进展进行综述.

Acute pancreatitis is a kind of acute inflammatory medium reaction caused by pancreatic enzyme activation within pancreatic tissue by its own digestion.It may induce systemic inflammatory medium reaction and cause multiple organfailure,even cause death of the patients with acute pancreatitis.In recent years,a lot of research data indicate that activation of NF-kappa B and oxidative stress have played an important role in the occurrence and development of acute pancreatitis.Hence treatment of antioxidant supplement to patients with acute pancreatitis is deemed to a new research direction.Multiple studies have shown that simplex or associated antioxidant therapy is beneficial to acute pancreatitispatient with lower infection rate and other complications.At the same time,more studies of antioxidants such as various plant extracts in animal models have made progress.By reviewing the relevant experimental and clinical literature,the activation of NF-kappa B and the effect of oxidative stress on acute pancreatitis and the progress of antioxidant therapy for acute pancreatitis are reviewed.