下肢动脉硬化支架内再狭窄进展

Advances in the in-stent restenosis of lower extremity atherosclerotic occlusive disease

随着社会的老龄化,下肢动脉硬化闭塞症成为常见的血管疾病.介入技术已成为治疗该病的主要手段,但支架内再狭窄对治疗效果的破坏仍困扰着临床医师.近10年来,针对支架内再狭窄的发生机制,涌现出各种新的预防及治疗技术,尤其相关器材的研制取得巨大进步,从药物涂层球囊、切割球囊到覆膜支架、可吸收支架等,均不同程度地降低了支架内再狭窄的发病率.本文对下肢动脉硬化支架内再狭窄的发生机制及治疗措施的相关临床研究的最新进展进行综述,着重对各种新器材临床应用效果进行总结评价.

Arteriosclerotic occlussive disease of the lower extremeties has become a common disease of aging society.Interventional technique is the main method of treating this disease,however,in-stent restenosis various and will degenerate itstherapeutic effect significantly and bring big trouble to clinicians.In the last decade,prevention and treatment techniques have emerged on the underlying mechanismofin-stent restenosis.Particularly,great improvement has been made,because of the development of related devices,such as drug coated balloons,cutting balloons,viabahn stentand bioresorbable stent,all of which could reduce the incidence of in-stent restenosisto varying degrees.In this paper,the latest progress of clinical research on the mechanism and treatment of in-stent restenosis is reviewed,particularly,the clinical effects of these newdevices are analyzed and summarized.