中国人TNFα-308基因多态性与炎症性肠病之间关系的Meta分析

Association between TNFα-308 polymorphism and inflammatony bowel disease susceptibility in Chinese people: A Meta-analysis

目的 系统评价中国人TNFα-308基因多态性与炎症性肠病之间的相关性.方法 通过从中国知网、万方、维普数据库进行检索自建库起截至2017年7月发表的文献,检索主题词为“TNFα”“基因多态性”与“炎性肠病”并结合自由词“单核苷酸多态性”“核酸多态性”“溃疡结肠炎”“克罗恩病”“非特异性肠炎”.利用Revman 5.3与Stata SE12.0软件进行统计学分析,并通过x2检验来判断异质性并合并效应量来分析中国人TNFα-308基因多态性与炎症性肠病之间的关系.结果 有6篇文献满足准入标准,共1 463例患者,其中病例组(炎症性肠病患者)536例,对照组(正常人群)927例.溃疡性结肠炎患者TNFα-308基因多态性的显性基因模型OR=1.32(95％ CI:0.95～ 1.84,x2 =21.58,P＜0.05),隐性基因模型OR=0.86(95％ CI:0.30 ～2.46,x2 =3.02,P＞0.05).经异质性分析与敏感性检验后,剔除影响性较大的原始研究,结果与先前一致且可信度更高.结论 中国人TNFα-308基因多态性与克罗恩病之间无明显关联,而相对于A基因,野生型G基因可能具有更高的溃疡性结肠炎易感性.

Objective To evaluate the association between TNFα-308 polymorphism and inflammatory bowel disease susceptibility in Chinese people.Methods The literatures about the association between TNFα-308 polymorphism and inflammatory bowel disease were collected by searching related database until July 2017.The theme words included 'TNFα gene polymorphism inflammatory bowel disease' and 'the free words' included 'single nucleotide polymorphism nucleic acid polymorphism ulcerative colitis Crohn's disease nonspecific enteritis' were used for searching,then x2 wasapplied test to determine the combined effect heterogeneity and then analyzed the relationship between TNFα-308 polymorphism and inflammatory bowel disease disease through recessive and dominant model.Results A total of 6 references met inclusion criteria,and there were 536 patients in the case group (patients with inflammatory bowel disease) and 927 patients in the control group (normal people) healthy controls were included in this study.Recessive model OR =0.86 (95％ CI:0.30-2.46,x2 =3.02,P ＞ 0.05),Dominant model OR =1.32(95％ CI:0.95-1.84,x2 =21.58,P ＜ 0.05),After heterogeneity analysis and sensitivity test,the original research with more influence was excluded,and the final results with higher credibility were consistent with previous one.Conclusion Compared to A alleles,an individual who carries G alleles is more susceptible to ulcerative colitis,while Crohn's disease has no business with the polymorphism of TNFα.