血清巨噬细胞炎性蛋白-2在心力衰竭合并肺部感染诊断中临床价值研究

The clinical value researchon diagnosing for patients with heart failure and pulmonary infection by MIP-2

目的：探讨血清MIP-2、IL-6及CRP水平对心衰合并肺部感染患者的诊断价值。方法：分析2014年1月～2015年12月87例在我院接受心力衰竭患者的临床资料，其中42例合并肺部感染列为观察组，45例单纯患有心力衰竭的患者划为对照组。结果：观察组患者血清MIP-2及CRP水平明显高于对照组，差异具有统计学意义；观察组患者随着心功能分级的升高，血清中MIP-2、CRP水平随之升高，差异具有统计学意义。观察组IV级患者血清中IL-6水平明显高于II级和III级患者，差异具有统计学意义；ROC曲线显示，当MIP-2取值62.01pg/mL时对心衰合并肺部感染患者的诊断敏感性为90.48%，特异性88.89%，诊断价值优于IL-6及CRP。结论：MIP-2、IL-6及CRP可作为对心衰合并肺部感染患者诊断指标，其中以MIP-2的诊断价值较高，对心衰合并肺部感染患者的诊断和治疗具有一定的临床研究价值。

Objective To investigate The clinical value researchon diagnosing for patients with heart failure and pulmonary infection by MIP-2、IL-6and CRP. Methods 87 patients with heart failure in our hospital were enrolled from December 2015 to January 2014, 42 patients with pulmonary infection were selected as the observation group, and 45 patients with heart failure were divided into control group. Results Serum MIP-2, IL-6 and CRP levels in observation group with were significantly higher than the control group, the difference was statistically significant;In the observation group, with the increase of cardiac function, the level of CRP and MIP-2 was increased, the difference was statistically significant . The serum levels of IL-6 in the obser-vation group were significantly higher than those of II and III patients, the difference was statistically significant;ROC curve shows that when the MIP-2 value is 62.01 pg/mL, the diagnose sensitivity was 90.48%, specificity is 88.89%, diagnostic value is better than that of IL-6 and CRP. Conclusion MIP-2, IL-6 and CRP can be used as diagnostic indicators for patients with heart failure and pulmonary infection, and the diagnostic value of MIP-2 is high, it has a certain clinical value for the diagnosis and treatment of heart failure with pulmonary infection.