血清胃蛋白酶原与胃泌素检测对慢性萎缩性胃炎的诊断价值

Serum pepsinogen and gastrin detection in the diagnosis of chronic atrophic gastritis value

目的：研究血清胃蛋白酶原与胃泌素检测对慢性萎缩性胃炎的诊断价值。方法：选取2014年1月～2015年12月在我科行胃镜检查诊断为慢性胃炎的患者200例，按根据组织病理学诊断结果分为观察组及对照组各100例，对照组为慢性非萎缩性胃炎组，观察组为慢性萎缩性胃炎组，通过酶联免疫吸附试验（ELISA）法来定量测定空腹血清PGⅠ、PGⅡ和G-17的数值水平，并计算PGⅠ/PGⅡ的比值（即PGR）。采取14C-呼气试验判定幽门螺杆菌（Hp）的感染情况。结果：观察组的PG-Ⅰ的值（129.44±62.43）、G-17的值（9.78±15.49）均明显低于对照组的（151.62±76.32）、（18.92±18.88），且经统计学分析差异均具有显著性。观察组PGR的值（10.11±5.23）低于对照组的（10.96±7.22），但经统计学分析差异不具有显著性。HP阳性的PG-Ⅰ值（124.41±65.88）、PGR的值（8.97±7.74）均明显低于HP阴性的（154.20±65.15）、（11.65±5.78），且经统计学分析差异均具有显著性。HP阳性的G-17的值（10.84±15.53）低于HP阴性的值（10.69±19.13），但经统计学分析差异不具有显著性。结论：血清PG和G-17水平的降低提示慢性萎缩性胃炎可能，应行胃镜以及活检检查明确诊断，且Hp感染与PG水平的变化有关。

Objective To study the serum pepsinogen and gastrin detection in the diagnosis of chronic atrophic gastritis value. Methods Select January 2014 to December 2015 in our department received 200 patients with chronic gastritis di-agnosed by gastroscopy, according to pathological diagnosis were divided into observation group and control group with 100 cases in each, for chronic non atrophic gastritis group in the control group, the observation group for chronic atrophic gastritis group, by enzyme linked immunosorbent assay (ELISA)to quantitatively determine the level of fasting serum PG I and PG II and G-17 numerical, and calculate the PG I/PG II ratio (PGR). The 14C urea breath test method to determine the infection of Helicobacter pylori (HP). Results In the observation group, the PG I values (129.44±62.43), G-17 value (9.78±15.49)were significantly lower than those of the control group (151.62±76.32), 18.92±18.88), and the statistical analysis of differences has significant difference . The value of PGR (10.11±5.23)in the observation group was lower than that in the control group (10.96 ±7.22), but the difference was not statistically significant . HP positive value of PG-I (124.41±65.88), PGR value (8.97± 7.74)were significantly lower than HP negative (154.20±65.15), (11.65±5.78), and the difference was statistically significant . The value of HP positive G-17 (10.84±15.53)was lower than that of HP negative value (10.69±19.13), but the difference was not statistically significant . Conclusion The decrease of serum PG and G-17 levels suggests that chronic atrophic gastritis may be diagnosed by gastroscopy and biopsy, and Hp infection is related to the changes of PG levels.