IVIG早期静滴治疗新生儿溶血的疗效研究

The effect of early intravenous infusion of IVIG in the treatment of neonatal hemolytic disease

目的：探讨丙种球蛋白早期大剂量静脉滴注（IVIG）治疗新生儿 ABO 溶血的临床效果。方法：选择2012年1月～2015年1月本院儿科治疗的90例 ABO 溶血患儿进行回顾性分析，其中早期组48例（出生后即进行血清学试验确诊后给予 IVIG2.0g/kg/d，连续3d），常规组42例（出现黄疸症状后，待血清学试验确诊后给予0.4g/kg/d 丙种球蛋白静滴治疗），对比两组患儿的治疗效果。结果：治疗前，早期组和常规组患儿的 Hb、TBIL、血尿 Cysc 测定值、NBNA 评分差异均无统计学意义；治疗后，早期组的 TBIL、血尿 Cysc 测定值显著的低于常规组，差异具有统计学意义，早期组的 NBNA 评分高于常规组，差异具有统计学意义；早期组的退黄时间、光疗时间显著的低于常规组，差异具有统计学意义。结论：早期 IVIG 治疗新生儿 ABO 溶血具有较好的临床效果和安全性。

Objective Study of gamma globulin in early high dose intravenous (IVIG) clinical effect of the treatment of neo-natal ABO hemolytic. Methods Select January 2012 ~ January 2015 90 cases of children with ABO hemolytic hospital pedi-atric therapy were retrospectively analyzed, including 48 cases of early (after birth after a serological test confirmed given IVIG 2.0g / kg / d, continuous 3d), 42 cases in routine group (jaundice symptoms, to be diagnosed with serologic tests administered 0.4g / kg / d intravenous gamma globulin treatment), compared to the therapeutic effect of two groups of children. Results Before treatment, the children of the early group and the conventional group Hb, TBIL, hematuria Cys c measurement values, NBNA scores were not significantly different; after treatment, TBIL early group, hematuria Cys c measured values significantly lower than conventional group, the difference was statistically significant, the early group NBNA score higher than the conventional group, the difference was statistically significant; jaundice time early group, significantly lower than the time of phototherapy conventional group, the difference was statistically significant. Conclusion Early IVIG treatment of neonatal ABO hemolytic has better clinical effect and safety.