高同型半胱氨酸血症与缺血性脑血管病的相关性

Correlation between homocysteine and ischemic cerebrovascular disease

目的：探讨高同型半胱氨酸血症（HHCY）与缺血性脑血管病（ICVD）的相关性。方法：选取2011年9月～2015年12月我院神经内科收治的130例脑梗死（CI）患者、67例短暂性脑缺血发作（TIA）患者以及同期我院体检科确诊的90例非 ICVD 患者（对照组）作为研究对象，采用循环酶法检测所有研究对象的血清同型半胱氨酸（HCY），分析血清 HCY 水平与 ICVD 病变类型、病情严重度的相关性。结果：①三组研究对象血清 HCY 水平相比差异有统计学意义，对照组血清 HCY 水平显著低于 CI 组与 TIA 组，CI 组与 TIA 组之间血清 HCY 水平相比差异无统计学意义。② ICVD 患者血清 HCY 水平与其美国国立卫生院神经功能缺损量表（NIHSS）评分之间无相关性。③三组研究对象高甘油三酯血症、高胆固醇血症、糖尿病、高血压等危险因素百分率相比差异有统计学意义，对照组上述危险因素百分率均显著低于 CI 组与 TIA 组，CI 组与 TIA 组上述危险因素百分率相比差异无统计学意义。④采用多因素 Logistic 回归分析 ICVD 发生的危险因素，HHCY、高甘油三酯血症、高血压等3个指标具有统计学意义，高胆固醇血症、糖尿病等2个指标无统计学意义。结论：HHCY 是 ICVD 发生的独立危险因素，但 HHCY 与ICVD 病变类型、病情严重度无相关性。

Objective To investigate the relationship between homocysteine (HHCY) and ischemic cerebrovascular disease (ICVD). Methods In September 2011 and 2015 December in our hospital from Department of Neurology, 130 cases of cerebral infarction (CI) patients, 67 cases of transient ischemic attack (TIA) patients and the same period in our hospital medical depart-ment confirmed the 90 patients with ICVD patients (control group) as the research object, using enzymatic cycling assay for detecting serum all the research object of the same type of homocysteine (Hcy) measurement and correlation analysis between serum level of homocysteine (Hcy) and ICVD lesion type and severity. Results In the three groups, the serum Hcy levels com-pared to the difference was statistically significant, the control group, the serum Hcy level was significantly lower than that in the CI group and TIA group, CI group and TIA group between serum level of homocysteine (Hcy) compared no significant . There was no correlation between the level of serum HCY in patients with ICVD and the neurological deficit scale (NIHSS) score of the National Institutes of Health. Compared to the percentage of 3 groups of hypertriglyceridemia, hypercholesterolemia hyperlipi-demia, diabetes, hypertension and other risk factors for difference was statistically significant, control group, the risk factors of percentage were significantly lower than those in CI group and TIA group, percentage of CI group and TIA group the risk factors compared no significant . Using multivariate logistic regression analysis of risk factors of ICVD and HHcy, high triglyceride hy-perlipidemia, hypertension and other three indexes with statistical significance, the two indicators of high cholesterol, diabetes and no statistical significance . Conclusion HHCY is an independent risk factor for the occurrence of ICVD, but HHCY is not related to the type of ICVD and the severity of the disease.