急性闭角型青光眼应用生物羊膜移植与丝裂霉素联合小梁切除术后临床疗效及意义

The significance and clinical application of biological amnion transplantation for glaucoma trabeculectomy combined with mitomycin after acute closed

目的 :探究生物羊膜移植与丝裂霉素技术联合小梁切除术对急性闭角型青光眼治疗的临床效果及意义。方法 :选取我院接治的47例急性闭角型青光眼患者,根据手术治疗方法不同划分,24例(30眼)单纯小梁切除术患者列为对照组,23例(29眼)生物羊膜与丝裂霉素联合小梁切除术患者列为观察组。对比两组患者患眼术后1周、4周、12周的视力、眼压、滤过泡及前房等情况差异。结果 :两组患者在术后1周、4周、12周时间点患眼视力、眼压较术前均有不同程度差异,且在术后各时间点观察组患者患眼视力较对照组改善显著,眼压也均小于对照组;观察组29眼中未有浅前房发生且只有1例眼出现非功能型滤过泡,对照组30眼中出现5例眼浅前房及6例眼非功能型滤过泡,差异均有统计学意义。结论 :采用常规的小梁切除术联合应用生物羊膜移植及丝裂霉素技术治疗急性闭角型青光眼,术后患者视力恢复好,眼压控制效果理想,减少了并发症的发生,手术安全有效且成功率高,值得临床上广泛关注和应用。

Objective To explore biological amniotic membrane transplantation and mitomycin C combined with trab-eculectomy on the clinical effect and significance of the treatment of acute angle closure glaucoma.Methods In our hospital treated47 cases of acute angle closure glaucoma patients, according to different surgical methods divided24 cases (30 eyes) trabeculectomy in patients as a control group,23 cases (29 eyes) of biological amnion and mitomycin C combined with trab-eculectomy in patients as the observation group. Visual acuity, intraocular pressure, filtering bleb and anterior chamber were compared between the two groups after1 weeks,4 weeks,12 weeks after surgery.Results Two groups of patients after1 weeks, 4 weeks and12 weeks time point of the visual acuity, intraocular pressure than before were different, and at each time point af-ter operation in the observation group the visual acuity was significantly improved, intraocular pressure was less than the control group; the observation group of29 eyes and no shallow ante-rior chamber only1 cases of ocular non functional blebs,30 eyes of control group occurred in5 cases of shallow anterior chamber and6 cases of ocular non functional bleb, the dif-ferences were statistically significant.Conclusions Using conventional trabecular resection combined with amniotic membrane transplantation and mitomycin C application of biological technique in the treatment of acute angle closure glaucoma, the postoperative visual acuity recovery, ideal intraocular pressure control effect, reduce the incidence of complications, safe and effective operation and high success rate, which is worthy of wide attention and application.