摘要
目的 :探讨间苯三酚静脉滴注联合坦索罗辛口服辅助体外冲击波碎石(ESWL)治疗泌尿系结石的临床疗效。方法 :以结石直径<0.6cm并行体外冲击波碎石(ESWL)后24h内的上尿路结石患者150例为研究对象,随机分为A组、B组及C组。所有患者给予常规治疗。A组给予间苯三酚注射液40mg溶于5%葡萄糖250ml注射液中静脉滴注,1次/日;B组给予坦索罗辛0.2mg,口服,1次/日;C组给予坦索罗辛联合间苯三酚注射液,其中坦索罗辛用法用量与B相同;间苯三酚注射液用法用量与A相同。治疗2周后比较3组患者的结石排出率、结石清除率、;平均结石排出时间、石街形成率、肾绞痛发作次数、镇痛药使用人次及治疗期间而不良反应发生情况。结果 :组间比较:治疗2周后,3组的结石排出率、结石清除率、平均结石清除时间、石街形成率、肾绞痛发作率及镇痛药使用率之间具有明显区别,差异具有统计学意义,3组之间的不良反应发生率比较无显著性差异。组内两两比较:C组的结石排出率及结石清除率显著高于另外两组,平均结石排出时间、肾绞痛发作率及镇痛药使用率显著低于另外两组,差异均具有统计学意义;C组的石街形成率显著低于A组,B组的平均结石排出时间明显短于A组。结论:间苯三酚静脉滴注联合坦索罗辛口服辅助ESWL可增加结石排出率,缩短结石排出时间,降低肾绞痛发作率及镇痛药使用率且药物不良反应发生率与单用坦索罗辛或间苯三酚无明显区别,是一种安全有效的上尿路结石治疗方案。
Objective To study the phloroglucinol intravenous drip combined tan solo symplectic oral supplements extra-corporeal shock wave lithotripsy (ESWL) clinical efficacy in the treatment of urinary calculi.Methods Stone diameter <0.6 cm parallel within24 h after extracorporeal shock wave lithotripsy (ESWL) of 150 patients with urinary stones on as the research object, were randomly divided into group A, group B and group C. All patients were given conventional treatment. A group was given40 mg phloroglucinol dissolved in 250m l5% glucose injection intravenous drip,1 time/day; Group B to tan solo symplec-tic0.2 mg, oral,1 time/day; Group C give tan solo symplectic joint phloroglucinol intravenous drip, usage and dosage is the same as the A, B two groups.3 groups of patients2 weeks after treatment in the stone, stone clearance rate, average discharge rate of stone, the average calculi clearance time, the stone street formation rate, discharge time attack frequency of renal colic, analge-sics application people and during treatment and adverse reactions occur.Results Comparison between groups:2 weeks after treatment,3 groups of stone, stone clearance rate, average discharge rate stones clearance time, the stone street formation rate, onset of renal colic attendances and use of analgesics, has an obvious difference between statistically significant difference, the incidence of adverse reactions between three groups was no significant difference. Comparing two groups: group C discharge rate and stones clearance is significantly higher than the other two groups, the average calculi clearance time, renal colic attacks at-tendances and analgesic use was significantly lower than the other two groups, the differences were statistically significant; The stone street formation rate of group C was significantly lower than that of group A, group B average calculi clearance time sig-nificantly shorter than group A.Conclusion Phloroglucinol intravenous drip combined tan solo symplectic oral auxiliary ESWL can increase the rate of calculous eduction, shortening the time of stone removal, reduce the number of renal colic attacks and analgesic use people and the incidence of adverse drug reactions on tan solo symplectic or phloroglucinol no significant differ-ence, is a kind of safe and effective treatment on urinary stones.
出处
《湖南师范大学学报(医学版)》
2017年第3期-,共4页
Journal of Hunan Normal University(Medical Sciences)