左氧氟沙星影响肺结核患者PCT、CRP水平及临床疗效的研究

The study of PCT、CRP changes and clinical efficacy on Tuberculosis patients treatment by levofloxacin

目的 :探讨左氧氟沙星对于肺结核患者血清降钙素原(PCT)、超敏C反应蛋白(Hs-CRP)水平以及临床疗效的影响。方法 :选择2013年1月~2015年12月在河北省胸科医院明确诊断复治涂阳肺结核患者80例,随机分成实验组(左氧氟沙星+常规抗结核药)、对照组(常规抗结核药),比较两组患者痰涂片转阴率、X线胸片以及PCT、CRP水平。结果 :实验组痰菌阴转率显著高于对照组。实验组组总有效率为90%显著高于对照组的67.5%。治疗后两组患者PCT、CRP水平均明显降低。CRP水平较对照组患者明显降低,而PCT水平无明显差异。结论 :左氧氟沙星联合抗结核药物可以改善肺结核患者PCT、CRP水平,有一定的临床疗效。

Objective To discuss the influence of PCT、CRP results and clinical efficacy on pulmonary tuberculosis treated by levofloxacin.Methods Eighty cases of retreatment pulmonary tuberculosis in the Chest Hospital of Hebei Province were enrolled in the research. All patients were divided into two groups named experimental group (levofloxacin+ standard regi-ments) and control group (standard regiments) at random. Sputum smear, X-ray, PCT, CRP assays were detected in the patients before treatment, and after therapy, respectively.Results Compared with the control group, the sputum conversion rate on the experimental group was more higher. Results The total effective rate of it is 90%, and comparing with the control group (67.5%) there is a significant difference. After different therapy, average number of spots in PCT, CRP assays both decreased consider-ably compared with that before treatment. and the lever of CRP assay was more lower than the control group. However, after the treatment, PCT assays had no statistical differences between the two groups.Conclusions Levofloxacin combined standard regiments have clinical curative effect by means of reducing the lever of PCT、CRP assays.