血清CEA、AFP、CA199、CA125在肝炎及肝硬化患者中的检测意义

The detective significance of the serum CEA, AFP, CA199 and CA125 in patients with hepatitis and liver cirrhosis

目的 :探析血清癌胚抗原(CEA)、甲胎蛋白(AFP)、糖链抗原199(CA199)及癌抗原125(CA125)在慢性病毒性肝炎及肝炎后肝硬化患者的早期诊断及治疗中的检测价值。方法 :分析2014年11月~2016年9月在我院接受治疗的109例肝病患者的临床资料,其中慢性病毒性肝炎患者61例(慢性肝炎组),肝炎后肝硬化者48例(肝炎后肝硬化组)。另外选取同期在我院体检的28例健康体检者作为本次研究的健康对照组。比较各组间的一般资料、血清CEA、AFP、CA199、CA125水平及其阳性率。结果 :三组患者的一般资料无显著差异性。慢性肝炎组者的血清AFP、CA199与CA125水平显著较健康对照组高,中、重度患者显著较健康对照组高,而CEA水平与健康对照组间无显著差异性,且慢性肝炎组者的血清AFP与CA199、CA125水平随着疾病病情的加重而升高。肝炎后肝硬化者的血清AFP、CA199与CA125水平显著较健康对照组高,其中代偿组患者的血清AFP、CA199与CA125水平显著较失代偿组低。慢性肝炎组的血清AFP、CA199与CA125的阳性率均显著较肝炎后肝硬化组低,但两组的CEA阳性率无显著差异性。结论 :动态监测慢性病毒性肝炎及肝炎后肝硬化患者血清AFP、CA199与CA125水平在肝癌、微量腹水的早期诊断及肝硬化代偿期与失代偿期的鉴别中具有重要的检测意义,值得推广。

Objective Our retrospective study was aimed toanalyze the detective value of the serum CEA, AFP, CA199 and CA125 in diagnosis and treatment of patients with chronic viral hepatitis and liver cirrhosis.Methods Clinical data of109 patients with hepatosisreceived treatment at our hospitalfrom November,2014 to September,2016 was retrospectivelyanalyzed, including61 patients with chronic viral hepatitis (chronic hepatitis group) and48 patients with liver cirrhosis (liver cirrhosis group).28 healthy persons at the same time at our hospital were chosen as the control group. The general information, the levels and the positive expression rate of the serum CEA, AFP, CA199 and CA125 in groups were compared.Results The general information in three groups had no statistical difference . The levels of the serum AFP, CA199 and CA125 in chronic hepatitis group were obviously higher than those in control group, and they in moderate, severe group were obviously higher than those in control group. The levels of CEA in groups had no statistical difference. The levels of the serum AFP, CA199 and CA125 in chronic hepatitis group were increasing as the the degree of severity. The levels of the serum AFP, CA199 and CA125 in liver cirrhosis group were obviously higher than those in control group, and the levels in compensatory cirrhosis group were obvi-ously lower than those in discompensatory cirrhosis group . The positive expression rate of the serumAFP, CA199 and CA125 in chronic hepatitis group were obviously lower than those in liver cirrhosis group, and the positive expression rate of the serum CEA in two groups had no statistical difference.Conclusion The dynamic monitoring of the levels of the serum AFP, CA199 and CA125 in patients with chronic viral hepatitis and liver cirrhosis play important roles in early diagnosis and treatment of liver cancer and trace ascites and the identification between compensatory cirrhosis patients and discompensatory cirrhosis pa-tients, which is worth promoting.