利福昔明联合常乐康治疗小儿急性腹泻的临床疗效及其消炎、心肌保护作用

The clinical effect of rifaximin combined with Chang lekang on treating children with acute diarrhea and its role in anti-inflammatory, myocardial preservation

目的 :探究利福昔明联合常乐康治疗小儿感染性腹泻的临床效果及其消炎、心肌保护作用。方法 :选择我院2014年1月~2016年6月收治的184例小儿腹泻患者,根据随机数字表法,平均分为观察组及对照组,每组92例。比较两组患者临床疗效及心肌酶、炎症因子水平。结果 :观察组的总有效率为95.65%,显著高于对照组的总有效率(83.29%);治疗后,两组患者血清谷草转氨酶(AST),乳酸脱氢酶(LDH),磷酸肌酸激酶(CK)以及肌酸激酶同工酶(CK-MB)的水平均显著降低,且观察组显著低于对照组;治疗后,两组患者的白介素6(IL-6)、白介素10(IL-10)以及肿瘤坏死因子(TNF-α)的水平显著降低,且观察组患者血清炎性因子水平显著低于对照组。结论 :利福昔平联合常乐康治疗小儿急性腹泻临床效果显著,可显著控制炎症反应并具有一定的心肌保护作用,值得临床推广。

Objective To explore the clinical effect of rifaximin combined with Chang lekang on treating children with acute diarrhea and its role in anti-inflammatory, myocardial preservation. Methods 184 cases treated in our hospital from January, 2014 to June, 2016 were randomly divided into the observation group and control group with each group of 92 cases. The clini-cal effect and levels of inflammatory cytokine and myocardial enzyme were compared in the two groups. Results The total effec-tive rate in the observation group was 95.65%, which was significantly higher than the control group (83.29%). After therapy, the level of AST, LDH, CK and CK-MB were obviously decreased compared with those of before therapy, and those of the observa-tion group were significantly lower than the control group; Similarly the level of IL-6、IL-10 and TNF-α in all the two groups were obviously decreased compared with those of before therapy, and those of the observation group were significantly lower than the control group. Conclusion Rifaximin combined with Chang lekang was effective methods in treating children with acute diarrhea and could decrease levels of inflammatory cytokine as well as myocardial enzyme, which deserve clinical expan-sion.