摘要
Objectives:Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial Methods:Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial.Self-reported history on prior OSA medical therapy was collected at enrollment,including OSA diagnosis date,CPAP start and stop dates,oral appliance trial,and reasons for discontinuation or non-adherence.Results:The cohort consisted of 929 participants,83％ male,with a mean age (53.9 ± 10.5) years.Ninety percent (n =835) had complete CPAP information including 47％ (n =435) who discontinued therapy prior to enrollment and 43％ (n =400) who were still attempting CPAP but had inadequate adherence.Abandonment rates were 60％ at 1-year,73％ at 3-years,and 86％ at 5-years.Oral appliance therapy was attempted by 171 patients for mean (1.8 ± 2.3) years,with 81％ abandonment at 1 year,89％ at 3-years,and 94％ at 5-years.Conclusions:In this CPAP-refractory cohort,high rates of CPAP abandonment were reported in the first several years with approximately half of the participants not receiving any treatment despite being diagnosed for ＞5 years.Close clinical follow-up and consideration of alternative treatment options is indicated in all OSA patients in order to ensure adequate longitudinal care.
Objectives:Analyze the obstructive sleep apnea (OSA) treatment history in a group of participants who enrolled in a hypoglossal nerve stimulation trial Methods:Moderate-severe OSA patients with difficulty adhering to CPAP presented for enrollment in a multicenter trial.Self-reported history on prior OSA medical therapy was collected at enrollment,including OSA diagnosis date,CPAP start and stop dates,oral appliance trial,and reasons for discontinuation or non-adherence.Results:The cohort consisted of 929 participants,83％ male,with a mean age (53.9 ± 10.5) years.Ninety percent (n =835) had complete CPAP information including 47％ (n =435) who discontinued therapy prior to enrollment and 43％ (n =400) who were still attempting CPAP but had inadequate adherence.Abandonment rates were 60％ at 1-year,73％ at 3-years,and 86％ at 5-years.Oral appliance therapy was attempted by 171 patients for mean (1.8 ± 2.3) years,with 81％ abandonment at 1 year,89％ at 3-years,and 94％ at 5-years.Conclusions:In this CPAP-refractory cohort,high rates of CPAP abandonment were reported in the first several years with approximately half of the participants not receiving any treatment despite being diagnosed for ＞5 years.Close clinical follow-up and consideration of alternative treatment options is indicated in all OSA patients in order to ensure adequate longitudinal care.
