高效联合抗反转录病毒治疗服药依从性管理指南的构建研究

Development of clinical practice guidelines for the management of adherence to highly active antiretroviral therapy

目的：构建适合我国国情的高效联合抗反转录病毒治疗（HAART）服药依从性管理指南。方法通过对31位利益相关人群的质性访谈，423例HIV感染者和艾滋病患者的问卷调查，以及采用ADAPTE工作组制订的方法对10份艾滋病护理相关指南的指南改编，采用系统评价再评价方法对10份艾滋病护理相关的系统评价/Meta分析的系统评价再评价。结果本次指南构建共纳入10份指南和10份系统评价/Meta分析，形成了HAART服药依从性管理指南。结论本次构建的指南可应用性较好，总体质量较高，建议在艾滋病护理实践中引入并使用本指南。

Objective To develop the clinical practice guidelines for the management of medication adherence to highly active antiretroviral therapy (HAART) in China. Methods The development methods included qualitative interview of 31 stakeholders, questionnaire survey of 423 PLHIV, adaptation of 30 clinical practice guidelines related to AIDS care, and overviews of reviews of 44 systematic reviews/Meta-analysis. Results 10 clinical practice guidelines and 10 systematic reviews/Meta-analysis were included. The clinical practice guidelines for the management of HAART were formed. Conclusions The formed clinical practice guidelines showed better applicability and higher general quality. It is recommended to use the guidelines in AIDS care.