脉波指示剂连续心输出量监测指导下重症心力衰竭患者液体管理的效果观察

Observation about the effects of fluid management for patients with severe heart failure under the guidance of PICCO

目的：应用脉波指示剂连续心输出量（PICCO）监测指标指导重症心力衰竭患者的容量管理，以更好的指导临床液体治疗及护理。方法选择64例ICU的心功能均为Ⅳ级的心力衰竭患者，所有纳入患者均行PICCO监测，采用随机数字表法随机分为对照组和试验组，每组各32例。对照组应用中心静脉压（CVP）监测技术进行液体管理；试验组应用PICCO监测技术进行液体管理。比较2组患者ICU住院时间及28 d病死率、日均液体出入量、达到液体负平衡时间，并观察试验组治疗前后心功能指数（CFI）和容量指标[胸腔内血容量指数（ITBVI）、舒张末期总容量指数（GEDVI）、血管外肺水指数（EVLWI）]变化。结果试验组治疗后ITBVI、GEDVI、EVLWI恢复正常，CFI 改善，治疗前各指数分别为（1203.41±111.08）ml/m2、（1087.78±66.91）ml/m2、（12.91±3.54）ml/kg、（2.91±0.29）L · min-1· m-2；治疗后分别为（895.50±50.27）ml/m2、（728.19±73.33）ml/m2、（6.51±0.75）ml/kg、（4.61±0.69）L·min-1·m-2，差异有统计学意义（t=-18.52～54.42， P＜0.05）；试验组在ICU住院时间及28 d病死率、日均液体出入量、达到液体负平衡时间与对照组比较差异有统计学意义（t=-17.19、-76.80、-12.38，χ2=4.43，P＜0.05）。结论与CVP指导的常规液体管理相比，PICCO监测指标能更好的指导重症心力衰竭患者液体管理及护理，使抢救成功率明显提高，治疗效果显著提升，改善预后，促进患者康复。

Objective To guide fluid management for sever heart failure patients by using PICCO indicators, in order to direct clinical fluid management and nursing care. Methods Sixty-four heart failure patients with level IV cardiac function were randomly divided into the control group and the experimental group according to random number table, and each one had 32 patients. Fluid management for patients in the control group was implemented with CVP monitoring technology, while the patients in the experimental group accepted PICCO monitoring technology as fluid management. Then compare these indicators between the two groups--length of stay in ICU, mortality rate of 28 days, daily fluid intake, output and time of achieving negative fluid balance, and observe the change of cardiac function index (CFI) and capacity indicators (ITBVI, GEDVI, EVLWI) in the experiment group before and after treatment. Results Indicators of ITBVI、GEDVI、EVLWI in the experiment group recovered to normal state and CFI improved. The indicators which had mentioned above was (1 203.41±111.08) ml/m2, (1 087.78±66.91) ml/m2, (12.91±3.54) ml/kg, (2.91±0.29) L·min-1·m-2 respectively when before the treatment, while the values after the treatment was (895.50 ± 50.27) ml/m2, (728.19 ± 73.33) ml/m2, (6.51 ± 0.75) ml/kg, (4.61 ± 0.69) L · min-1 · m-2, the difference was significant (t=-18.52-54.42, P<0.05). The length of stay in ICU, mortality rate of 28 days, daily fluid intake, output and time of achieving negative fluid balance of the experimental group were&nbsp;significantly lower than those in the control group(t=-17.19,-76.80,-12.38, χ2=3.26, P<0.05). Conclusions PICCO monitoring indicators are better than CVP method in the aspect of fluid management for patients with sever heart failure, which can increase the rescue success rate, promote the treatment effect, improve prognosis, and promote the rehabilitation of patients.