生物反馈电刺激疗法联合盆底肌功能锻炼对我国女性压力性尿失禁有效性的Meta分析

A Meta-analysis of effect of biofeedback electrical stimulation therapy combined with pelvic floor ;muscle functional exercise on female stress urinary incontinence in China

目的：系统评价生物反馈电刺激疗法联合盆底肌功能锻炼对女性压力性尿失禁的效果。方法利用计算机检索中国学术期刊网全文数据库（中国知网）、万方数据库、中文科技期刊全文数据库、维普期刊资源（在线）相关文献，根据Note Express软件进行文献筛选和查重，对纳入符合标准的随机（RCT）或非随机对照试验（NRCT）文献采用RevMan 5.2软件进行数据合并分析。结果共纳入10篇文献，采用固定效应模型分析，纳入研究对象为969例，试验组496例，对照组473例。调查结果显示，生物反馈电刺激疗法联合盆底肌功能锻炼可以显著改善我国女性压力性尿失禁的状况（OR=7.70，95%CI 5.07～11.70，P<0.01）。控制大样本量研究进行敏感性分析，结果显示OR=8.51,95%CI 5.43～13.34，P<0.01，研究结果稳定性高，结论可靠。结论生物反馈电刺激疗法联合盆底肌功能锻炼是一个安全有效的防治女性压力性尿失禁的方法，值得进一步推广应用。

Objective To assess systematically the effect of biofeedback electrical stimulation therapy combined with pelvic floor muscle functional exercise on female stress urinary incontinence in China. Methods Relative literatures were searched by computer at home according to the inclusion and the exclusion criteria,which were analyzed by RevMan5.2 software, and literature selection and repetition were used according to the Note Express software. Results A total of 10 studies of randomized controlled or not randomized controlled trial were brought into the study by fixed effects model. A total of 969 cases were selected into the study, 496 in experimental group and 473 in control group. The results showed that biological feedback electrical stimulation therapy combined with pelvic floor muscle functional exercise could significantly improve the situation of female stress urinary incontinence ( OR=7.70, 95%CI 5.07-11.70, P<0.01). Removing the large sample literature, the results of sensitivity analysis were similar (OR=8.51, 95%CI 5.43-13.34, P<0.01), which indicated that the results were stable and reliable. Conclusions Biofeedback electrical stimulation therapy combined with pelvic floor muscle function exercise is a safe and effective method for the prevention and treatment of female stress urinary incontinence, worthy of further promotion.