摘要
目的 观察盐酸羟考酮缓释片联合锝[99Tc]亚甲基二膦酸盐治疗骨转移瘤疼痛的临床疗效.方法 将骨转移瘤疼痛患者96例随机分为A组和B组,每组48例.A组采用盐酸羟考酬缓释片治疗,B组采用盐酸羟考酮缓释片联合锝[99Tc]亚甲基二膦酸盐治疗.两组均以15d为1个治疗周期.比较两组疼痛治疗效果、生活质量、止痛起效时间、止痛持续时间、盐酸羟考酮缓释片日均用量等指标的变化.结果 A组疼痛治疗效果总有效率为66.7％(32/48例),B组为91.7％(44/48例),差异具有统计学意义(P＜0.05);A组生活质量改善率为37.5％(18/48例),B组为64.6％(31/48例),差异具有统计学意义(P＜0.05);B组止痛起效时间明显快于A组(P＜0.05);B组止痛持续时间明显长于A组(P＜0.05);B组盐酸羟考酮缓释片日均用量明显低于A组(P＜0.05).结论 盐酸羟考酮缓释片联合锝[99Tc]亚甲基二膦酸盐治疗骨转移瘤疼痛能够明显提高患者的疼痛治疗效果和生活质量,并且能够降低盐酸羟考酮缓释片的日均用量.
Objective To explore the clinical effects ofoxycodone combined with technetium [99Tc]methylenediphosphonate in the treatment of patients with pain of bone metastasis.Methods Ninety-six patients with bone metastasis pain were randomly divided into two groups:group A and group B,48 cases in each group.The patients in group A were received oxycodone,and in group B received oxycodone combined with technetium [99Tc] methylenediphosphonate.All the course of treatment was 15 days.The therapeutic effect,quality of life,onset time of pain relief,duration of pain relief and average daily dosage of oxycodone were compared between the two groups.Results The total effective rate was 66.7％ (32/48 cases) and 91.7％ (44/48 cases) in group A and B respectively,with statistically significant difference hetween the two groups (P ＜ 0.05).The improvement rate of quality of life was 37.5％ (18/48 cases) and 64.6％(31/48 cases) in group A and B respectively,with significant difference (P＜ 0.05).The onset time of pain relief in group B was significantly faster than that in group A(P＜ 0.05).The duration of pain relief in group B was significantly longer than that in group A(P＜ 0.05).The average daily dosage of oxycodone in group B was significantly less than that in group A (P＜ 0.05).Conclusion Oxycodone combined with technetium [99Tc] methylenediphosphonate can significantly improve the therapeutic effect of pain and quality of life in patients with pain of bone metastasis,and reduce the average daily dosage of oxycodone.
出处
《实用疼痛学杂志》
2016年第5期354-357,共4页
Pain Clinic Journal
