新生儿感染性疾病体液免疫功能的初步观察

Observation on Humoral Immunity in Neonatal Infections

我们分析了住院治疗的61例新生儿皮下坏疽等疾病的患几血中免疫球蛋白及补体C3在治疗前后的含量对比,报道如下: 对象及方法 研究对象为61例生后30日内住院治疗的感染患儿,7～15日龄的34例(55.77%),16～30日龄的27例(44.23%).61例中,新生儿皮下坏疽41例,新生儿急性乳腺炎6例,头度感染5例,急性血源性骨髓炎4例,脐炎3例,急性脓胸及手部感染各1例.

Dynamic changes of immunoglobulin and complement C_3 in 61 neonates with infections were observed by means of single agar diffusion. The values of IgG, IgM and IgA were found significantly higher than normal(P＜0.01)except the IgG value in those of 7-15days of age. On the mend, the values of IgM and IgA decreased gradually, followed by the decrease in IgG. The complement C_3 had a lower primary value. On the mend, it rose gradually but the rise had little significance(P＞0.05)The values of IgG of the septic group is lower thaa those of local infection group(P＜0.01). But the values of IgA and IgM showed no difference between the two groups(P＞0.05). The humoral immunity system undergoes some characteristic change during the infection. Although the examination of the immunoglobulins and complement C_3 were affected by various factors, its regularity can reflect the severity of the disease and the body's ability to resist against disease. It can be regarded as one of indications guiding treatment and judging prognosis.