四川地区儿童臀肌挛缩症调查报告

A Survey of Gluteal Muscle Contracture Caused by Injections Among Children in Sichuan Province

1987年10月至1988年4月,作者在13630位3～12岁儿童的流行病学调查中,检出注射性臀肌挛缩症患者137例.在5688以生理盐水或注射用水稀释的青霉素作臀肌注射的儿童中检出患者2例;而7942例以苯甲醇稀释的青霉素作注射的儿童中检出患者135例.前者患病率为0.035%,后者为1.7%,两者相差48倍以上,此结果不仅验证了注射因素确系臀肌挛缩的病因,还发现苯甲醇青霉素溶液是重要的致病因子.且其浓度愈高,针数愈多,致病力亦愈强.如今后放弃使用苯甲醇,尤其是2%的苯甲醇作青霉素溶媒可望大幅度降低发病率.

One-hundred-thirty-seven cases of gluteal muscle contracture were found in 13630 children followed penicillin injections,aged 3-12 years,from Apr.1987 to Oct.1988.This survey showed that the gluteal muscle contracture was predominently an iatrogenic disease.Among 7942 children receiving injections of penicillin diluted with benzyl alcohol 135 cases were suffering from the gluteal muscle contracture,while among 5688 children receiving injections of penicillin diluted with distilled water,only 2 developed contracture.Benzyl alcohol was apparently the most significant etiological factor.The severity of the lesion and the symptoms was closely related to the concentration of the benzyl alcohol and the frequency of injections It is hopeful to reduce the morbidity of muscular contractures by giving-up the use of benzyl alcohol.