翼状胬肉逆行切除联合术中应用丝裂霉素C临床研究

Clinical research in combination with the application of mitomycin C in pterygium retrograde resection

目的 比较翼状胬肉逆行切除术与联合术中应用丝裂霉素C治疗翼状胬肉的临床疗效.方法 对96例102眼采用随机数字表法分为两组:观察组(50例52眼)为翼状胬肉逆行切除联合术中应用丝裂霉素;对照组(46例50眼)为单纯翼状胬肉切除术.比较两组患者术后复发率、治愈率.结果 随访12~24个月,观察组治愈51眼,仅1眼复发,复发率1.9%治愈率98.1%.对照组治愈40眼,复发10眼,复发率20.0%,治愈率80.0%.两组临床疗效比较差异有统计学意义(χ2=8.66,P<0.05).两组术后无严重并发症发生.结论 翼状胬肉逆行切除联合术中应用丝裂霉素C手术操作简单,复发率低,治疗效果好。

Objective To compare the therapeutic effect of retrograde resection in combination with the application of mitomycin C for the treatment of pterygium. Methods Totally 96 cases 102 eyes divided into two groups at random, on the basis of random number table. Observation Group (50 cases 52 eyes) for pterygium retrograde resection combined with the application of mitomycin C. Comparison Group (46 cases 50 eyes) for pterygium resection only. The recurrence rate and cure rate after pterygium surgery between the two groups were compared. Results All patients were followed up for 12-24 months. The cured eyes are 51 and only 1 eye in observation group recurred after surgery. The recurrence rate was 1.9% and the cure rate was 98.1%. While the cured eyes are 40 and 10 eyes in comparison group recurred after surgery. The recurrence rate was 20.0%and the cure rate was 80.0%. The difference of therapeutic effect between the two groups had statistically significant (χ2=8.66, P<0.05). There were no severe complications after surgery. Conclusions Retrograde resection of pterygium is an easy operation. Combined with the application of mitomycin C, it has low recurrence rate and good treatment effect,and is suitable for popularization and application in primary hospitals and Africa.