探讨中药生大黄和急性胰腺炎患者肿瘤坏死因子、白细胞介素-6、白细胞介素-8水平的关系

To investigate the relationship between tumor necrosis factor, interleukin 6, interleukin 8 levels in patients with rhubarb and acute pancreatitis

目的 分析中药生大黄对急性胰腺炎患者肿瘤坏死因子(TNF)、白细胞介素(IL)-6、IL-8水平的影响.方法 选取2010年10月至2015年10月收治的95例患者为研究对象,根据治疗方法的不同将患者分为对照组(47例)和观察组(48例);对照组患者采用常规西医治疗,观察组在对照组治疗的基础上给予中药生大黄治疗.检测两组患者治疗前后TNF、IL-6、IL-8水平并进行比较.结果 两组患者治疗后血清TNF、IL-6、IL-8水平显著低于治疗前(P<0.05);治疗后观察组患者血清TNF、IL-6、IL-8水平明显优于对照组,差异有统计学意义(P<0.05).结论 中药生大黄应用于急性胰腺炎治疗中能有效抑制患者炎性细胞因子的释放,减轻胰腺炎症反应,改善患者临床症状,促进患者康复.

Objective To explore the effect of rhubarb on tumor necrosis factor (TNF), interleukin 6 (IL-6) and interleukin 8 (IL-8) levels in patients with acute pancreatitis. Methods Selected in our hospital in October 2010 to October 2015 were 95 cases of patients as the research object, according to the different treatment methods of the patients were divided into control group (47 cases) and observation group (48 cases);the control group was treated with conventional western medicine therapy, the observation group in the control treatment group on the basis of given Chinese medicine rhubarb treatment. Detection of two groups before and after treatment in patients with TNF, IL-6, IL-8 levels. Results After treatment, the patients in the two groups of serum TNF, IL-6 and IL-8 levels were significantly lower than those before treatment (P<0.05);after treatment, observation group, serum TNF, IL-6, IL-8 levelS was significantly better than the control group, compared the two groups has statistical significance (P<0.05). Conclusions The traditional Chinese medicine students application of Rhubarb in treatment of severe acute pancreatitis (SAP) can effectively inhibit the in patients with inflammatory cytokine release, reduce inflammation, improve the clinical symptoms of the patients and promote the recovery of the patients.