Box-Behnken设计优选古方乌发膏基质组成

Optimization of the Matrix Matrix Formulation of Cuban Hair Cream Using the Box-Behnken Design-response Surface Method

目的:采用Box-Behnken设计优化古方乌发膏的最佳基质组成。方法:以乳膏基质外观性状、小鼠皮层没食子酸(GA)的含量等多个指标为响应值,采用单因素试验结合Box-Behnken设计进行配方优选研究,对十六醇、十二烷基硫酸钠(SDS)、丙二醇、氮酮的用量进行优化,确定基质成分的最佳配比。结果:古方乌发膏中三者的最佳配比为:十六醇20g、十二烷基硫酸钠0.5g、丙二醇1.5%、氮酮2.5%。结论:运用Box-Behnken设计响应面法优选的古方乌发膏成型工艺稳定可行。

Objective:To optimize matrix formulation of Cuban Hair Cream by response surface method.Methods:Taking appearance,the content of GA in mice cortex as comprehensive evaluation index,response surface method was employed to optimize matrix formulation with hexadecanol,SDS,propylene glycol,azone.Results:The best proportion were:hexadecanol 20 g,SDS 0.5g,propylene glycol 1.5%,azone 2.5%.Conclusion:It is feasible to optimize the preparation process of Cuban Hair Cream by using the Box-Behnken design response surface method.