放疗联合免疫检查点抑制剂的研究进展

Advances in Combination of Radiotherapy and Immune Checkpoint Inhibitors

近期免疫检查点抑制剂成为癌症治疗的主流,在免疫治疗期间接受放疗的患者中观察到远隔效应。放疗可诱导或提高抗肿瘤免疫,使抗肿瘤治疗取得重大突破。放疗还可引起免疫源性细胞死亡,并可促进肿瘤微环境中T细胞的募集及其功能。放疗协同免疫检查点抑制剂恢复了抗肿瘤T细胞的活性剂功能,该协同作用显著提高了治疗效果,使存在抗肿瘤免疫的患者获益。

Recently,immune checkpoint inhibitors are becoming mainstream cancer therapies ,abscopal responses are observed in patients who receive radiotherapy during immunotherapy .Radiotherapy can induce or promote anti-tumor immu-nity,making a great breakthrough in anti-tumor therapy.Radiotherapy can induce an immunogenic cell death and promote the recruitment and the function of T cells within the tumor microenvironment .Radiotherapy in synergy with immune check-point inhibitors recovers the activation and function of antitumor T cells , therefore this combination benefits patients who have antitumor immunity .