目标温度管理在成人心脏停搏患者中的应用

Application of targeted temperature management in the treatment of cardiac arrest in adult patients

心脏停搏(CA)复苏成功率低,病死率高,且存活患者多遗留神经功能障碍,严重影响患者生活质量.诸多证据表明,目标温度管理(TTM)可提高CA患者存活率,改善CA患者的神经功能,故被国际复苏委员会(ILCOR)推荐用于CA复苏成功后仍然昏迷的成年患者.本文就近年来成人CA后脑损伤的病理机制及TTM在CA患者临床管理中的应用进展进行综述,以期为TTM的临床应用提供一定的参考依据.

Cardiac arrest (CA) is a fatal condition with low resuscitation rate and high mortality rate. Most of the survivors have neurological sequelae affecting their quality of life. Targeted temperature management (TTM) has been suggested by a number of studies to increase the survival rate and improve neurological outcome of CA. It is highly recommended by the International Liaison Committee on Resuscitation (ILCOR) for unconscious patients after resuscitation. In this review, we discuss the pathological mechanism of brain injury in CA and applications of TTM in adults with CA, with the aim of providing valuable information for clinical application.