FoxO1因子与β细胞去分化的关系

The relationship between FoxO1 factor and beta cells dedifferentiation

2型糖尿病是由于β细胞功能缺陷导致不同程度的胰岛素缺乏和组织胰岛素抵抗的慢性代谢性疾病.β细胞功能下降是2型糖尿病进展的中心环节,而胰岛β细胞去分化作为胰岛功能减退的重要机制之一,近年有研究显示,叉头转录因子O亚组1(FoxO1)活性下降与β细胞去分化密切相关.研究FoxO1参与β细胞去分化的具体发生机制并促进去分化的β细胞再分化将会为2型糖尿病的预防和治疗提供新的思路.

Type 2 diabetes is a chronic metabolic disorder caused by a deficiency of beta cell func-tion leading to varying degrees of insulin deficiency and insulin resistance. The decline of beta cell function is the central part in the development of type 2 diabetes. The dedifferentiation of pancreatic beta cells is one of the important mechanisms of islet dysfunction. In recent years, it has been shown that the decrease of the activity of the transcription factor forkhead box O1 (FoxO1) is closely related to the dedifferentiation of beta cells. The study of the specific mechanism of FoxO1 involved in the dedifferentiation of beta cells and the redifferentiation of the differentiated cells will provide new ideas for the prevention and treatment of type 2 diabetes.