胃息肉合并结肠息肉发生的相关因素分析

Analysis of related factors of colonic polyps existence in patients with gastric polyps

目的 探讨胃息肉患者并发结肠息肉的相关因素.方法 回顾性分析2012年1月1日至2014年1月1日在海军总医院消化内科住院期间行胃肠镜检查并确诊胃息肉的病例,分为胃肠息肉组(病例组)及单纯胃息肉组(对照组),应用病例-对照研究,筛选危险因素.结果 年龄分布中≥60岁人群病例组明显高于对照组;单因素分析显示两组患者年龄≥60岁、幽门螺旋杆菌(HP)感染、吸烟、饮酒、胆固醇、高血压的差异均有统计学意义(x2值分别为11.538、9.350、4.190、5.103、8.992、4.038;P均＜0.05);多因素Logistic分析显示性别、年龄＞60岁、HP感染阳性、糖尿病、吸烟、饮酒、高血脂为胃肠息肉发生的危险因素(P均＜0.05),OR值从大到小依次为年龄、HP感染、饮酒、高脂血症、吸烟、糖尿病、性别.结论 ≥60岁的女性、HP感染阳性、糖尿病、高脂血症、吸烟、饮酒的胃息肉患者更易患有肠息肉,建议行肠镜检查;其中,合并有HP感染阳性的≥60岁女性应作为重点筛查人群,如同时伴有高脂血症应重点筛查结直肠原位癌.

Objective To investigate the risk factors for gastrointestinal polyps.Methods A retrospective analysis was performed.The patients who undergone gastrointestinal endoscopy and diagnosis gastric polyps were selected who hospitaled in the Navy General Hospital from January 2012 to January 2014 and divided into cases group(patients with gastric polyps and colonic polyps) and control group (patients with gastric polyps).The information was recorded.Results The case of over 60 years of age distribution in case group was significantly higher than the control group.Single factor analysis showed that the indices including age,HP infection,smoking,drinking,high cholesterol and hypertension were significantly different from that of control group (x2 =11.538,9.350,4.190,5.103,8.992,4.038;P ＜ 0.05) after adjusting the interactions of the factors.Multi factor Logistic analysis showed that the risk of gastrointestinal polyps was significantly related with sex,age over 60 years old,HP infection,diabetes,smoking,drinking and hyperlipoidemia(P＜0.05),and the OR value from small to large were age,HP infection,alcohol drinking,hyperlipidemia,smoking,diabetes and gender.Conclusion The female gastric polyp patients who were over 60 years old,HP infection positive,diabetes,hyperlipidemia,smoking,drinking are more likely to suffer from intestinal polyps,and they were suggested to perform colonoscopy.Among them,women with HP positive infection and the age over 60 are high risk population.If they complicated with hyperlipidemia,they should had a screening for colorectal carcinoma in situ.