不同手术入路治疗SiewertⅡ型和Ⅲ型食管胃结合部腺癌患者的效果比较

Efficacy and prognosis of different surgical approach in siewert Ⅱ and Ⅲ gastroesophageal junction adenocarcinoma

目的 探讨不同手术入路治疗SiewertⅡ、Ⅲ型食管胃结合部腺癌的效果.方法 选择SiewertⅡ、Ⅲ型食管胃结合部腺癌患者共148例进行回顾性研究,包括经胸入路组58例和经腹入路组90例.对手术结果进行比较;随访2年,比较患者的生存情况.结果 经胸入路组与经腹入路组患者手术时间[(329.5±84.3)、(202.4±84.5)min,t=15.431、P＜0.001)、切缘残端阳性率(8.62％与1.11％,x2=5.763、P=0.012)、胸腔积液(13.79％与2.22％,x2=10.462、P＜0.001)、肺部感染发生率(15.52％与1.11％,x2=12.574、P＜0.001)、淋巴结清扫数[(16.7±4.3)、(22.6±5.5)个,t=6.321、P=0.004)比较差异均有统计学意义.两组患者术中出血量、肿瘤直径、吻合口漏或出血的发生率、住院时间比较差异均无统计学意义(P均＞0.05).经胸入路组1年生存率73.24％,2年生存率为53.43％;经腹入路组1年生存率为78.42％,2年生存率为57.51％,两组比较差异无统计学意义(P=0.453、P=0.311).结论 SiewertⅡ、Ⅲ型食管胃结合部腺癌患者经腹入路的手术方式明显优于经胸入路,可更好地进行腹部淋巴结的清扫,不破坏胸腔的完整性,避免相关的并发症发生.

Objective To investigate the surgical approach of Siewert Ⅱ and Ⅲ gastroesophageal junction adenocarcinoma.Methods A total of 148 cases with Siewert Ⅱ,Ⅲ type patients were prospectively studied.The patients were divided into two groups,including transthoracic approach group (58 cases) and transabdominal approach group(90 cases).The results of surgery were compared.Patients were followed up for 2 years and survival rate were compared.Results In transthoracic approach group and transabdominal approach group,operative time ((329.5 ± 84.3) min vs.(202.4± 84.5) min,t =15.431,P ＜ 0.001),the positive rate margin stump (8.62％ vs.1.11％,x2 =5.763,P =0.012),pleural effusion (13.79％ vs.2.22％,x2 =10.462,P ＜0.001) and pulmonary infection rate (15.52％ vs 1.11％,x2 =12.574,P＜ 0.001) were significantly higher than transabdominal approach group,and number of lymph node dissection ((16.7 ± 4.3) vs.(22.6± 5.5),t =6.321,P =0.004) was significantly less than transabdominal approach group.In incidence of blood loss,tumor diameter,anastomotic leakage (or bleeding) and discharge time,there was no significant difference (P ＞0.05).One-year survival rate of transthoracic approach group was 73.24％,and 2-year survival rate was 53.43％.Oneyear survival rate of transabdominal approach group was 78.42％,and 2-year survival rate was 57.51％.Survival rate of two groups showed no significant difference (P =0.453,0.311).Conclusion Transabdominal surgical approach in Siewert Ⅱ,Ⅲ patients is better than transthoracic approach,can better carry out abdominal lymph node dissection,does not destroy the integrity of the chest,and avoid the occurrence of related complications.