中重度围绝经期综合征患者不同治疗方法的临床分析

Clinical analysis of different methods in the treatment of severe in peri-menopausal syndrome in 216 case

目的 探讨中重度围绝经期综合征的的有效治疗方法,提高围绝经期及绝经后妇女的生活质量.方法 回顾性分析216例确诊为中重度围绝经期综合征患者的临床资料.单纯激素补充治疗(HT)组60例,单纯中医药治疗组90例,激素补充和中医药综合治疗组66例.于治疗3个月后随访症状改善和不良反应情况.结果 3组治疗3个月后患者的临床症状均有不同程度改善,单纯激素补充治疗、单纯中医药治疗、激素补充和中医药综合治疗组总有效率分别为90％ (54/60)、82％ (76/90)、100％(66/66),3组比较,差异均具有统计学意义(x2=13.160,P＜0.01).单纯激素补充治疗、单纯中医药治疗、激素补充和中医药综合治疗组治疗3个月不良反应分别为27例(45％)、1例(1％)、4例(6％),差异有统计学意义(x2=60.720,P＜0.01),中医药治疗组、综合治疗组不良反应发生率高于单纯激素治疗组,差异有统计学意义(P均＜0.01),中医药治疗组和综合治疗组比较,差异无统计学意义(P＞0.05).结论 在治疗中重度围绝经期综合征时,对于有激素补充治疗适应证无禁忌证者,建议采取中西医综合治疗,对有激素补充禁忌证或不愿意激素补充治疗者,中医药治疗也有不错的效果.

Objective To observe the effective treatment of severe in peri-menopausal syndrome,and improve the quality of life of women in perimenopausall and postmenopausal women.Methods We review the different treatment methods in the 216 patients diagnosed with moderate to severe menopausal syndrome.Group A:simple hormone replacement therapy (HT) of 60 cases.Group B:simple treatment of traditional Chinese medicine of 90 cases.Group C:hormone replacement and comprehensive therapy of Chinese medicine of 66 cases.Follow up the improvement of symptoms and adverse reactions after the treatment one and three month respectively.Results The three groups after treatment in patients with clinical symptoms were improved after three month.Efficient comparisons among third group,the differences were statistically significant (90％ (54/60),82％ (76/90),100％ (66/66);x2 =13.160,P ＜ 0.01).Adverse reactions of 3 treatment group comparison difference had statistical significance (45％ (27/60,1％ (1/90),6％ (4/66);x2 =60.720,P ＜0.01).Compared with pure hormone treatment group,treatment group of Chinese medicine,comprehensive treatment group adverse reactions happen was less,the difference was statistically significant(P＜0.01).Chinese medicine treatment group and combined treatment group,there was no statistically significant difference (P ＞0.05).Conclusion Severe menopausal syndrome with hormone replacement therapy indications without contraindications suggestions take comprehensive treatment of traditional Chinese and Western medicine,The hormone supplement contraindications or unwilling to hormone replacement therapy,also has good effect of Chinese medicine treating.