Photofrin光动力辅助治疗青年晚期结直肠癌的近期效果观察

Short-term effect of Photofrin photodynamic adjuvant therapy for young people with advanced colorectal cancer

目的 观察Photofrin光动力辅助治疗青年晚期结直肠癌的近期效果及不良反应.方法 选择我院2010年9月至2014年2月采用半导体激光光动力辅助治疗青年晚期结直肠癌患者共23例作为试验组,选择同期行放化疗的晚期结直肠癌患者30例作为对照组.试验组患者给予光敏剂Photofrin,以2 mg/kg速度静脉滴注,48 h后经内镜导入光导纤维,并给予630 nm强度的激光照射,2d后经内镜清除坏死组织并对原有病灶和新发现病灶给予复照,之后根据具体情况清除患者病灶部位坏死组织.对比分析两组患者的近期疗效及不良反应.结果 试验组患者的总有效率(69.57％)显著高于对照组(40.00％),差异有统计学意义(P=0.035).试验组住院时间显著少于对照组[(13.47±4.46)h和(19.72±5.21)h,差异有统计学意义(P=0.036).试验组的不良反应发生率(30.43％)显著低于对照组(50.00％),差异有统计学意义(P=0.021).结论 对青年晚期结直肠癌患者采用光动力治疗近期效果较好,可以有效改善临床症状,减少并发症.

Objective To observe the short-term efficacy and adverse drug reaction of Photofrin photodynamic adjuvant therapy for advanced colorectal cancer in young persons.Methods Selected 23 cases consecutives diagnosed as advanced colorectal cancer in young persons from September 2010 to February 2014 arriving in the Central Hospital of Jiangmen as the experiment group who were received Photofrin photodynamic therapy,and chose 30 consecutives diagnosed as advanced colorectal cancer as the control group who were received radiotherapy and chemotherapy.Using Photofrin in 2 mg/kg photosensitizer, the speed of intravenous infusion,48 hours after endoscopic into optical fiber, laser irradiation and treated with 630 nm intensity,2 days after endoscopic removal of necrotic tissue and the original lesions and new lesions were found to give according to the specific circumstances, after the removal of necrotic tissue lesions.Then compare the effects and complications.Results The total efficacy rate in experiment group was significantly more than control groupthe differences were significant (69.57％ vs.40.00％, P =0.035).The in-hospital time in experiment group was significantly less((13.47±4.46) h vs.(19.72± 5.21) h, P =0.036).The adverse drug reaction rate in experiment group was significantly lower thant the control group (30.43％ vs.50.00％ ,P=0.021).Conclusion The Photofrin photodynamic therapy for advanced colorectal cancer in young persons may greatly improve clinical effect and decrease complication.