血清基质金属蛋白酶9、表皮生长因子检测对子宫肌瘤的诊断价值

Diagnostic value of Matrix metalloproteinase-9 and Epidermal growth factor in uterine myoma

目的 探讨血清基质金属蛋白酶9(MMP-9)、表皮生长因子(EGF)水平对子宫肌瘤诊断的临床价值.方法 选取73例手术治疗的子宫肌瘤患者和65名同龄健康女性作为病例组和对照组.用ELISA法测定两组血清MMP-9和EGF含量.结果 病例组MMP-9血清浓度及EGF血清浓度与对照组比较差异均有统计学意义[MMP-9水平:(1.72±0.36) mg/L与(1.28±0.25) mg/L,EGF水平:(342.16±128.65) ng/L与(209.84±100.34) ng/L;t值分别为8.241、6.678,P均＜0.01].MMP-9及EGF血清水平与子宫肌瘤的最大直径无关(P均＞0.05).结论 MMP-9和EGF对子宫肌瘤的诊断有一定的临床价值.

Objective To discuss the diagnostic value of Matrix metalloproteinase-9 (MMP-9) and Epidermal growth factor (EGF) in uterine myoma.Methods Seventy-three patients with uterine leiomyoma treated by surgery as treatment group,and 65 healthy women were selected as control group.The levels of MMP9 and EGF in both groups were detected by enzyme-linked immunosorbent assay method.Results The levels of MMP-9and EGF in treatment group were significantly higher than those of control group((1.72±0.36) mg/L vs.(1.28±0.25) mg/L, (342.16± 128.65) ng/L vs.(209.84± 100.34) ng/L;t =8.241,6.678;P ＜0.01).There were no relationships between the levels of MMP-9 and EGF with maximum diameter of uterine myoma (P ＞0.05).Conclusion Serum levels of MMP-9 and EGF have some clinical value in diagnosing uterine leiomyoma.