乳腺癌患者血清乳脂球表皮生长因子8、糖类抗原125及癌胚抗原的表达及其意义

Expression and significance of serum milk fat globule epidermal growth factor 8,carbohydrate antigen 125,carcinoembryonic antigen in patients with breast cancer

目的：探讨乳腺癌患者血清乳脂球表皮生长因子8（MFG?E8）、糖类抗原125（CA125）、CEA的表达及其临床意义。方法测定108例乳腺癌患者（乳腺癌组）、108例乳腺良性肿瘤患者（乳腺良性肿瘤组）的血清MFG?E8、CA125、CEA浓度，比较良恶性患者、转移与否患者各肿瘤标志物的浓度，分析单独及联合检测对乳腺癌的诊断价值。结果与乳腺良性肿瘤组[（207．2±47．1） ng／L、（8．64±2．86） U／ml、（1．38±0．37）μg／L]比较，乳腺癌组血清 MFG?E8[（5182．1±564．5） ng／L]、CA125[（34．22±7．20） U／ml]、CEA[（4．41±1．22）μg／L]均显著升高（t 值分别为91．27、34．31、24．70，P 均＜0．05）；与乳腺癌未转移者[（4814．4±351．1） ng／L、（24．13±5．71） U／ml]比较，转移者血清MFG?E8[（6362．8±678．4） ng／L]、CA125[（37．45±10．40） U／ml]浓度显著升高（t 值分别为15．47、8．53，P 均＜0．05），转移者、未转移者血清CEA浓度差异无统计学意义（ P＞0．05）；3项指标联合检测的敏感性为82．4％，均明显高于血清 MFG?E8、CA125、CEA 任一指标单独检测，诊断准确率为85．2％，显著高于CA125、CEA单独检测，差异均有统计学意义（ P均＜0．05）。结论血清MFGE8、CA125、CEA在乳腺癌患者中呈高表达状态，联合检测对于明确诊断以及治疗方案的选择具有一定指导意义。

Objective To explore the expression and clinical significance of serum milk fat globule epi?dermal growth factor 8(MFG?E8),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA) in pa?tients with breast cancer. Methods The levels of serum MFG?E8,CA125,CEA were detected in 108 cases pa?tients with breast cancer(breast cancer group) and 108 cases patient with benign breast tumors(benign breast tumor group). The level of each indicators between malignant and non?malignant,metastasis and non?metastasis were compared, and diagnosis value of breast cancer by individual and combined detection were ana?lyzed. Results Compared with benign breast tumors group((207. 2±47. 1) ng/L,(8. 64±2. 86) U/ml,(1. 38 ±0. 37) μg/L),the levels of serum MFG?E8,CA125 and CEA((5 182. 1±564. 5) ng/L,(34. 22±7. 20) U/ml,( 4. 41 ± 1. 22 ) μg/L ) were increased significantly in breast cancer group ( t=91. 27, 34. 31, 24. 70; P<0. 05). Compared with patients without metastasis((4 814. 4±351. 1) ng/L,(24. 13±5. 71) U/ml),the levels of serum MFG?E8,CA125((6 362. 8±678. 4) ng/L,(37. 45±10. 40) U/ml) were significantly increased in pa?tients with metastasis( t=15. 47,8. 53;P<0. 05) . There was no statistically significant difference on serum CEA between metastasis and non?metastasis( P>0. 05) . The sensitivity of combined detection of three indicators were 82. 4%,significantly higher than any of MFG?E8,CA125,CEA alone( P<0. 05) ,the diagnose accuracy rate was 85. 2%,significantly higher than CA125,CEA alone(P<0. 05). Conclusion The levels of serum MFG?E8, CA125,CEA in patients with breast cancer are over?expressed,combined detection has certain guiding signifi?cance for diagnosis and choice of therapeutic regimen.