血清KL-6黏蛋白及Clara细胞分泌蛋白检测在非小细胞肺癌的应用价值及其研究进展

Research progress and clinical significance of serum KL-6 mucin and Clara cell secretory protein non small cell lung cancer

KL?6黏蛋白（ KL?6 mucin）是由MUC1基因编码的一种糖蛋白，以往的众多研究表明KL?6有诊断肺间质性疾病的积极作用。近年来研究发现，KL?6有预测非小细胞肺癌转移复发的作用，并对肺癌的化疗、放疗和靶向治疗的疗效有评估作用。同样作为肺损伤的标记物，Clara细胞分泌蛋白（ CC16）对肺癌的抑制作用近年来也屡见报道，二者在非小细胞肺癌中的检测有重要的潜在价值。

KL?6 mucin( KL?6) is a glycoprotein encoded by the MUC1 gene,a number of previous stud?ies had indicated that KL?6 has a positive role in the diagnosis of interstitial lung disease?Recent studies have found that KL?6 has a role in predicting the recurrence of non?small cell lung cancer metastasis,and evaluation for the effect of chemotherapy,radiotherapy and targeted therapy for lung cancer?As a marker of lung injury,the inhibitory effect of Clara cell secretory protein ( CC16 ) on lung cancer has been reported repeatedly in recent years,and the potential value of the two in the detection of non small cell lung cancer is important.