吡哌酸对痢疾杆菌体外敏感试验和体内浓度测定

PIPEMIDIC ACID IN THE TREATMENT OF SHIGELLOSIS: DETERMINATION OF SENSITIVITY AND BLOOD CONCENTRATION

毗哌酸(Pi:pemidie Aoid)对革兰氏阴性菌抗菌效果较好,为探讨其对痢疾杆菌疗效,特收集痢疾菌888株进行体外试管法药敏试验,.同时测定57例口服本剂后血内浓度,为合理使用提供依据,现报告如下.

In vitro both 205 and 128 strains of shigella isolated from patients'and carriers'stoolwere found very sensitive to pipemidio acid(PPA).The average MIC of the former was only 1.7±O.77μg/ml and of the latter 2.2±O.72/μg/ml,and the average MBO was 4.0±O.98/μg/ml and 3.6±0.73/μg/ml respectively.When an adult took 1.0gm of PPA,the blood level could reach 6/μg/ml after one hour and its effective level could be stably maintained if the interval of medication was not longer than 4 to 6 hours.Long-acting PPA,PPA-CMC and PPA-Shellac,might apparently decrease both its liberation and absorption rate in vivo.If 1.5 gm of the long-acting PPA was given orally every 6 hours,the blood level could reach above 7/μg/ml after 2 hours.If the interval of medication Was 12 hours,the blood lovel did not drop obviously,and the effective level of one-day medioation could last 48 hours.If 4.0mg of PPA-CMC was given orally,the average highest blood level could reach 20.4μg/ml aftor 6 hours and its effective concentration might last more than 24 hours.Therefore.it is considered that PPA might be the better new synthsized drug for treating shigellosis,and the long acting PPA could offer a possibility of decreasing the times and lenthening the interval of medioation.