抗-HBc-IgM检测在原发性肝癌中的意义

DETECTION OF IgM ANTI-HBc IN PATIENTS, WITH PRIMARY HEPATIC CARCINOMA

为了解抗-HBc-IgM在原发性肝癌患者中的频率,我们对107例肝癌患者与107例外科住院患者进行了配对病例对照研究.结果提示,肝癌组抗-HBc-IgM43例阳性一(40.2%),对照组4例阳性(3.8%).配对比较相对危险性为40.0;43例抗-HBc-IgM阳性肝癌患者中42例HBsAg阳性(97.7%),28例HBsAg阴性肝癌患者中,仅1例抗-HBc-IgM阳性;抗-HBc-IgM在HBeAg阳性的患者中比抗-HBe阳性患者中高,分别为61.7%与37.1(P＜0.05).结果提示抗-HBc-IgM检测在研究肝癌发生发展中有一定价值.

Dept.of Epidemiology,Shandong Medieal UniversityIn order to understand the frequency of serum IgM anti-HBo in patients with primary hepatie carcinoma(PHC),igM anti-HBc was determined by ELISA in 107 patients with PHC and 107 patients admitted in:orthopaedic ward as control. HBsAg and anti-HBs were deternlined by SP-RIA,and anti-HBc,HBeAg,and anti-HBe by ELISA.HBV markers were found in 98.1%of patients with PHC and 57.9% of controls.IgM anti-HBo was found in 43 of 107 PHC patients(40.2%)and in 4 of 107 controls(3.8%).This finding indicates that IgM anii-HBc is more specifically associated with PHC than with the presence of HBsAg.Thus, the presence of IgM.anti-HBo in HBsAg carriers may be considered as one of the high risk factors in developing PHC.