HBsAg免疫复合物与HBeAg、HBV-DNA关系的观察

OBSERVATION ON THE RELATIONSHIP BETWEEN HBsAg IMMUNE COMPLEX AND HBeAg AND HBV-DNA

本文采用聚乙二醇--胰酶--反向血凝法对慢性活动性肝炎(CAH)46例,慢性迁延性肝炎(CPH)143例,无症状HBsAg携带者35例及健康人41名测定了乙型肝炎抗原免疫复合物(HBsAg-IC).发现CAH阳性率最高为60.9%,依次CPH为41.9%,HBsAg携带者为25.7%,健康人为阴性.HBsAg-IC阳性率和SGPT异常、血清HBeAg及HBV-DNA阳性有密切相关,提示血清HBsAg-IC与病毒复制有一定关系.

HBsAg immune complex(HBsAg-IC)was detected in 46 patients with chronic active hepatitis(CAH),143 with chronic persistant hepatitis(CPH),35 asymptomatic HBsAg carriers and 41 health persons by PEG-Trypsin-RPHA.It was found that the positive rate of HBsAg-IC was 60.9% in CAH,41.9% in CPH,25.9% in HBsAg carriers and negative in health persons.The positive rate of HBsAg-IC bore a close association with abnormal SGPT,serum HBeAg-positivity and HBV-DNA.It suggests that there is a certain relationship between HBsAg-IC and the replication of HBV.