糖皮质激素对乙型肝炎免疫调控的初步探讨

A PRELIMINARY STUDY ON IMMUNoREGULATORY EFFECT OF GLUCOCoRTICOIDS IN PATIENTS WITH HEPATITIS B

本文研究了糖皮质激素对乙型旰炎患者Ts活性的影响.20例正常人Ts活性为21～65%.23例慢性活动性肝炎、10例重型肝炎平均抑制率分别为-6.6%、-15.28%,均明显低于正常.19例慢性活动性肝炎的Ts经10-6M、10-5M氢化可的松培育后,活性较对照显著提高.4例重型肝炎患者Ts经10-6M氢化可的松培育后,活性有提高,但仍低于正常.皮质激素治疗4例慢性活动性肝炎,6例重型肝炎患者,有效者Ts活性显著提高,无效者提高不显著.

Con-A-induced suppressive function was investigated.The suppression percentage ranged from 21% to 65% in 20 control subjects.In 23 patients with chronic active hepatitis (CAH)and 10 with fulminant hepatitis tbe average values were-6.6% and -15.28% respecMvely,markedly lower than that of control subjects.After 10-6M and 10-5M of hydrocortisone in vitro incubated with the suppressers,the suppressive function was improved in 19 patients with CAH.10-6M of hydrocortisone improved the suppressive function in 4 patients with fulminant hepatitis in vitro,though the value remained lower than that of control subjects.10 patients with hepatitis B were treated with prednisolone,the function was improved significnatly in 5 patients,but it was not true in another 5.