凝血因子ⅩⅢ在病毒性肝炎患者血浆中的变化

PLASMA LEVELS OF BLOOD COAGULATION FACTOR ⅩⅢ SUBUNITS IN VIRAL HEPATITIS

本文采用了兔抗人因子ⅩⅢ亚基(ⅩⅢ-a)和兔抗人因子ⅩⅢb亚基(ⅩⅢ-b)抗血清借电免疫扩散法测定了21名正常人及103例瞒毒性肝炎患者血浆因子ⅩⅢ亚基水平,结果发现血浆因子ⅩⅢa亚基抗原(ⅩⅢ-a:Ag)及b亚基抗原(ⅩⅢ-b:Ag)在各组肝炎患者血浆中均有显著下降.其中7例死亡者中有2例肝硬化ⅩⅢ-a:Ag和ⅩⅢ-b:Ag与正常组比较分别为29.8%和44.7%,5例重型肝炎为33.4%和68%,并伴有凝血酶原时间延长和不同程度的出血现象.这些结果表明了ⅩⅢ-a:Ag和ⅩⅢ-b:Ag值的测定对诊断和估计肝病的严重程度以及了解凝血系统的状态具有实用价值.

By means of electro-immunodiffusion,plasma levels of blood coagulation factor ⅩⅢ subunit a antigen(ⅩⅢ-a:Ag)and subunit b antigen(ⅩⅢ-b:Ag)were measured in 21 normal subjects and 103 patients with various types of viral hepatitis.Both levels of plasma ⅩⅢ-a:Ag and ⅩⅢ-b:Ag decreased significantly in all types of the patients.Moreover,the more severe the disease is,the lower the plasma levels of ⅩⅢ-a:Ag and ⅩⅢ-b:Ag are.7 cases of the patients died,their average levels of plasma ⅩⅢ-a:Ag and ⅩⅢ-b:Ag were 29.8%and 44.7%respectively,which were even lower than those of other patients.The results showed that quantitive estimation of ⅩⅢ-a:Ag and ⅩⅢ-b:Ag had diagnostic and prodiagnostic value.