病毒性肝炎常用药物对大白鼠肝脏微循环及胆汁分泌的实验研究

STUDY ON HEPATIC MICROCIRCULATION AND BILE SECRETION IN RATS BY SOME DRUGS FOR TREATING VIRAL HEPATITIS

病毒性肝炎临床常用的几种药物(丹参、桃仁、川芎嗪、茵陈、毛冬青、赤芍、甘草甜素,Cynarin和联苯双酯)对大白鼠进行实验.药物经脾动脉入肝动脉进行对比研究.通过激光多普勒血流量仪及胆汁流量仪分别观察其肝脏表面微循环及其胆汁流晕的影响,用药韵大白鼠以盐水作对照,对照值做为:100%.根据用药前后肝脏表面微血管内流量的变化,结果提示:丹参、桃仁、川芎嗪、茵陈等药物有短期增快肝脏局部微循环血流量;毛冬青、赤芍主要加速胆汁分泌的作用;而甘草甜索、联苯双酯和Cynarin既无加快局部微循环,又无增加胆汁分泌的作用.

Nine drugs(Salvia Miltiornhiza Prunus kernal,Teramethyl pyrazine,Artenisia capilladis thumb llex pubesoens,Catechin,Cynarin,jGlyoerrhizin and Fruotus Schizandrae)commonly used for treating viral hepatitis were applied to rats.Blood flow on the liver surface was monitered by a laser-Doppler flowmetar.The control flow value was taken as 100%.Bile secretion rate(ul.min)was measured with a drop counted from a cannola in the common bile duct.Dose-response ourves were produced by infusion drugs into the hepatio artery via a cannula in the ligated splenic artery.The results showed that hepatic blood flow was increased by the Prunus kernel,Teramethyl pyrazine and Artemisia capillaris thumb.Bile seoretion was accelerated by the Ilex pubescens and Cateohin.Glycyrrhizin,Cynarin and Fructus Schixendrae had neither action on the hepatic microciroulation nor the bile secretion.