血清前白蛋白、转铁蛋白和抗胰蛋白酶检测及其在病毒性肝炎中的临床意义

CLINICAL SIGNIFICANCE OF MEASUREMENT OF SERUM PREALBUMIN TRANSFERRIN AND ALPHA1-ANTITRYPSIN IN VIRAL HEPATITIS

采用Lavorell氏火箭电泳法和改良Lane氏法分别对24名正常人和各型病毒性肝炎患者135例进行了血清前白蛋白(PA):转铁蛋白(Tf)和抗胰蛋白酶(а1-AT)检测.有45%的患者血清自蛋白正常而PA降低,其中3例PA降至零者均治疗无效死亡.各型肝炎的Tf含量均显著低于正常对照组,其下降程度依次为重型肝炎,肝硬化,慢性活动性肝炎、慢性迁延性肝炎和急性肝炎.血清а1-AT除急性肝炎时增高和重型肝炎降低外,其它各型肝炎均无明显变化.肝病时综合分析此三种蛋白的变化对肝炎的诊断,治疗和预后判断均有一定的临床意义.

Serum prealbumin(PA),transferrin (Tf) and α1-antitrypsin (α1-AT) were measured in 135 cases with different types of viral hepatitis and in 24 normal subjects by using Lanrell technique (rocket electrophoresis) and modified Lane technique respectively.Among them,serum PA levels were decreased (normal limit 32.54±6.18mg/dl)in 45%of the patients,3 of them died while their serum PA levels decreased to zero.However.their serum albumin still remained in normal range.Serum Tf levels in viral hepatitis were significantly lower than in normal control (253.87±52.21 mg/dl) and the degree of decrease of serum Tf was listed below:severe hepatitis＞liver cirrhosis＞chronic active hepatitis＞chronic persistent hepatitis＞acute hepatitis.The changes of serum α1-AT in viral hepatitis showed no significant difference,except its level increased in acute hepatitis and decreased in severe hepatitis.Therefore,the measurement of serum PA,Tf and α1-AT may be helpful in estimation of the diagnosis,treatment ad prognosis of liver disease.